Respiration, Artificial
Conditions
Keywords
Protocol-directed weaning, Mechanical ventilation, High-flow nasal cannula, Spontaneous breathing trial
Brief summary
Weaning patients from a ventilator is one of the most challenging processes in an intensive care unit. The investigators aimed to determine whether spontaneous breathing trial (SBT)-based protocol-directed weaning combined with the high-flow nasal cannula (HFNC) could be superior to routine SBT-based weaning in reducing the duration of mechanical ventilation (MV) in difficult-to-wean patients.
Interventions
PROCEDUREa weaning protocol
a weaning protocol that is combined spontaneous breathing trial (SBT) with the high-flow nasal cannula (HFNC)
Sponsors
JinyanXing
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* age ≥ 16 years old * MV for more than 48 hours * intubated or tracheostomized
Exclusion criteria
* pregnancy * irreversible respiratory failure caused by neurodegenerative disorders, such as Alzheimer disease, motor neuron disease, or multiple system atrophy * pre-existing decision to limit life support * waiving of MV during treatment * terminal stage of severe illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mechanical ventilation days | 60 days | the duration of mechanical ventilation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| re-intubated within 24 hours | 24 hours | re-intubated within 24 hours |
Countries
China
Contacts
Primary ContactJinyan Xing, Doctor
Outcome results
None listed