Intracerebral Hemorrhage；Circulating Exosomes
Conditions
Brief summary
The purpose of this study is to observe the relationship between the changes of circulating exosomes and the development and outcome of the disease in patients with intracerebral hemorrhage, and to search for early serum markers and potential intervention targets for disease monitoring in patients with intracerebral hemorrhage
Interventions
None listed
Sponsors
Tang-Du Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. No systematic treatment was given before admission; 2. The patients were diagnosed with cerebral hemorrhage, and had imaging evidence; 3. The age was more than 18 years old; 4. The patient or family member agrees to sign the informed consent.
Exclusion criteria
1. Hematoma is caused by secondary factors (intracranial tumor, arteriovenous malformation or aneurysm); 2. Bleeding into the ventricle; 3. Multiple cerebral hemorrhage; 4. The patient did not receive treatment in our hospital; 5. Severe disability, dementia, or organ dysfunction before onset 6. Coagulopathy or long-term use of anticoagulants 7. Hematoma affects brain stem 8. Subjects refused to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The type and content of circulating exosomes | within 24 hours of ICH | After the exosomes were isolated, RNA sequencing and proteome sequencing were performed to identify the change of circulating exosomes |
| Modified Rankin scale (mRS) scores | from onset to three months or six months | mRS scores was divided into seven grades (0-6). The higher the score, the more severe the symptoms |
Secondary
| Measure | Time frame |
|---|---|
| mortality | through study completion，an average of 1 year |
| hospital stay | From hospitalization to discharge，up to one month |
Countries
China
Contacts
Primary ContactXun Wu, M.D
Outcome results
None listed