Dynamic Changes in Some Facial Muscles After Hyaluronic Acid Filler Injection

Dynamic Changes in Some Facial Muscles After Superficial Versus Deep Hyaluronic Acid Injection: An Electromyographic Study

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05034965

Enrollment

Registered

2021-09-05

Start date

2021-10-31

Completion date

2022-10-31

Last updated

2021-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Changes in Facial Muscles Following Filler Injection

Brief summary

assess electrophysiological changes in some facial muscle dynamics following hyaluronic acid filler injection in superficial versus deep level of injection.

Detailed description

Participants will be subjected to injection of cross-linked hyaluronic acid fillers on both sides of the face in 3 different regions: temples, cheeks and chins. Each female will undergo: 1. Before injection: 1. Aesthetic facial clinical analysis. 2. Baseline quantitative surface electromyography. 3. Baseline digital photography. 2. Injection: Each female will receive the injection in the particular facial region at superficial level to the muscle (subcutaneous) on one side and the same amount at deep level to the muscle (supraperiosteal) on the other side. 3. One week after injection: 1. Follow up quantitative surface electromyography. 2. Follow up digital photography.

Interventions

DRUGhyaluronic acid filler injection

quantitative surface electromyography before injection(baseline) and one week after injection

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age: 20-60 years. 2. Sex: females. 3. Areas eligible for injection: temples, cheeks and chin.

Exclusion criteria

1. Active infection near the site of injection. 2. Pregnant or lactating women. 3. Patients suffering from any neuromuscular disorders. 4. Known allergy/hypersensitivity to hyaluronic acid fillers. 5. History of botulinum toxin injection in the last 4 months. 6. History of injection of fillers in the last 2 years. 7. Patients receiving any muscle relaxants. 8. Coagulation disorder or anticoagulants therapy.

Design outcomes

Primary

Measure	Time frame	Description
electrophysiological changes in some facial muscles	one week	baseline and follow up quantitative surface electromyography

Countries

Egypt

Contacts

Primary ContactMarwa Eldeeb

marwa.eldeeb16@alexmed.edu.eg+201200029774

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026