Acute Kidney Injury, Cardio-Renal Syndrome, Cardiomyopathies
Conditions
Keywords
Cardiac MRI
Brief summary
The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.
Detailed description
The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.
Interventions
DIAGNOSTIC_TESTCardiac magnetic resonance scan
Multiparametric cardiac magnetic resonance, including functional and structural parameter
Sponsors
University Hospital, Bonn
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Inclusion criteria
1. acute kidney injury and convalescence (GFR \> 45 ml/min/1.73m²). 2. patients who are 18 years of age or older
Exclusion criteria
1. underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes 2. known underlying disease wit potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy). 3. patients with persistent renal failure and GFR \< 45 ml/min/1.73m² 4. allergy to contrast media 5. patients who are using a intrauterinpessare for contraception 6. pregnant and breastfeeding women 7. patients with contraindications for MRI due to implants
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial T1 relaxation time | Measurement will be performed within 2 weeks after MRI scan. | T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\]. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial T2 relaxation time | Measurement will be performed within 2 weeks after MRI scan. | T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\]. |
| Myocardial ECV | Measurement will be performed within 2 weeks after MRI scan. | Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\]. |
| Myocardial strain | Measurement will be performed within 2 weeks after MRI scan. | Cardiac magnetic resonance feature-tracking will be used to asses left ventricular longitudinal, circumferential and radial strain. |
Countries
Germany
Contacts
Primary ContactJulian A Luetkens, PD Dr. med.
Backup ContactAlexander Isaak, PD Dr. med.
Outcome results
None listed