Bariatric Surgery Candidate
Conditions
Keywords
Bariatric, Weight regain, Metabolism
Brief summary
Is post-bariatric body contouring surgery prevent weight regain or no, and what is the effect on the patient's Metabolism? Few literature studies report body contouring surgery to be positively associated with maintained weight loss after obesity surgery but the measures of outcomes are diverse, and the collective magnitude of such an association is unknown. The changes in gastrointestinal hormones, adipokines, and cytokines as well as in hypothalamic neuropeptides and neurotransmitters resemble the changes observed in the anorexia/cachexia, suggesting that bariatric surgery triggers a catabolic state responsible for loss of appetite and prolonged body weight reduction. Weight regain after gastric bypass surgery occurs in about half of all patients within 2 years. About 50% of patients eventually gain a little weight back after hitting their low point. We need a more thorough evaluation to determine what factors - medical, psychological, lifestyle - are involved in the weight gain. One of the factors that seem to be responsible for the degree and durability of weight loss is post-bariatric body contouring procedures. However, metabolic consequences of removing excess subcutaneous adipose tissue by body contouring procedures have to a lesser extent been explored
Interventions
any post-bariatric body contouring surgery included
Sponsors
Study design
Eligibility
Inclusion criteria
* Post-bariatric (sleeve) patients will do body contouring surgery. * Post-bariatric patients has been stable within 5 kg for 3 months * Age between 20-60 years old. * patients use the determinant fixed diet.
Exclusion criteria
* Age below 20 and above 60 years old. * Non-compliance with the fixed diet. * psychotic patients. * Female patients seeking pregnancy. * Endocrine causes of obesity. * Bariatric surgery other than sleeve.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight Changes by Kilograms | 6 months | to know the effect of post-bariatric body contouring surgery in weight. Detect the weight cahnges of the patient 3 and 6 months after body contouring surgery and body mass index also measured |
| Level of Tumor Necrotizing Factor Alfa in Blood | 6 months | Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. Tumor necrotizing factor alfa increase afer bariatric surgery and we want to know if its complete on increasing after body contouring surgeries or decresae . Tnf-a is measured by pg/ml |
| Level of BNP in Blood | 6 months | Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. BNP highly increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in the level of BNP. BNP unit is pg/ml |
| Level of High Sensitive CRP in Blood | 6 months | Its a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. hsCRP increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in blood level of hsCRp. The unit of hsCRP is mg/dl. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient Satisfaction Score | 6 months | From 1 to 5 . 1 very dissatisfied 5 very satisfied Increase in number means increase satisfaction. |
Countries
Egypt
Contacts
Assiut University
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 60 Participants |
| Age, Continuous | 41 years STANDARD_DEVIATION 10 |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 60 Participants |
| Race (NIH/OMB) White | 0 Participants |
| Region of Enrollment Egypt | 30 participants |
| Sex: Female, Male Female | 23 Participants |
| Sex: Female, Male Male | 13 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 30 | 0 / 30 |
| other Total, other adverse events | 10 / 30 | 12 / 30 |
| serious Total, serious adverse events | 0 / 30 | 0 / 30 |