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Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism

Impact Of Post-Bariatric Body Contouring Procedures on Patient Body Weight and Metabolism

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05034081
Enrollment
60
Registered
2021-09-05
Start date
2021-09-01
Completion date
2025-08-15
Last updated
2026-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bariatric Surgery Candidate

Keywords

Bariatric, Weight regain, Metabolism

Brief summary

Is post-bariatric body contouring surgery prevent weight regain or no, and what is the effect on the patient's Metabolism? Few literature studies report body contouring surgery to be positively associated with maintained weight loss after obesity surgery but the measures of outcomes are diverse, and the collective magnitude of such an association is unknown. The changes in gastrointestinal hormones, adipokines, and cytokines as well as in hypothalamic neuropeptides and neurotransmitters resemble the changes observed in the anorexia/cachexia, suggesting that bariatric surgery triggers a catabolic state responsible for loss of appetite and prolonged body weight reduction. Weight regain after gastric bypass surgery occurs in about half of all patients within 2 years. About 50% of patients eventually gain a little weight back after hitting their low point. We need a more thorough evaluation to determine what factors - medical, psychological, lifestyle - are involved in the weight gain. One of the factors that seem to be responsible for the degree and durability of weight loss is post-bariatric body contouring procedures. However, metabolic consequences of removing excess subcutaneous adipose tissue by body contouring procedures have to a lesser extent been explored

Interventions

PROCEDUREbody contouring

any post-bariatric body contouring surgery included

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Post-bariatric (sleeve) patients will do body contouring surgery. * Post-bariatric patients has been stable within 5 kg for 3 months * Age between 20-60 years old. * patients use the determinant fixed diet.

Exclusion criteria

* Age below 20 and above 60 years old. * Non-compliance with the fixed diet. * psychotic patients. * Female patients seeking pregnancy. * Endocrine causes of obesity. * Bariatric surgery other than sleeve.

Design outcomes

Primary

MeasureTime frameDescription
Weight Changes by Kilograms6 monthsto know the effect of post-bariatric body contouring surgery in weight. Detect the weight cahnges of the patient 3 and 6 months after body contouring surgery and body mass index also measured
Level of Tumor Necrotizing Factor Alfa in Blood6 monthsIts a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. Tumor necrotizing factor alfa increase afer bariatric surgery and we want to know if its complete on increasing after body contouring surgeries or decresae . Tnf-a is measured by pg/ml
Level of BNP in Blood6 monthsIts a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. BNP highly increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in the level of BNP. BNP unit is pg/ml
Level of High Sensitive CRP in Blood6 monthsIts a clinical laboratory investigation will be done before the body contouring surgeries and 3 and 6 months after. hsCRP increase with catabolism after bariatric surgery and we want to know the effect of body contouring surgeries in blood level of hsCRp. The unit of hsCRP is mg/dl.

Secondary

MeasureTime frameDescription
Patient Satisfaction Score6 monthsFrom 1 to 5 . 1 very dissatisfied 5 very satisfied Increase in number means increase satisfaction.

Countries

Egypt

Contacts

STUDY_DIRECTORMohamed Shadad, Master

Assiut University

Baseline characteristics

Characteristic
Age, Categorical
<=18 years
0 Participants
Age, Categorical
>=65 years
0 Participants
Age, Categorical
Between 18 and 65 years
60 Participants
Age, Continuous41 years
STANDARD_DEVIATION 10
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
Race (NIH/OMB)
Asian
0 Participants
Race (NIH/OMB)
Black or African American
0 Participants
Race (NIH/OMB)
More than one race
0 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
Race (NIH/OMB)
Unknown or Not Reported
60 Participants
Race (NIH/OMB)
White
0 Participants
Region of Enrollment
Egypt
30 participants
Sex: Female, Male
Female
23 Participants
Sex: Female, Male
Male
13 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
0 / 300 / 30
other
Total, other adverse events
10 / 3012 / 30
serious
Total, serious adverse events
0 / 300 / 30

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 2, 2026