Cystic Fibrosis, Infertility, Female
Conditions
Keywords
Antral follicular count, Anti-Mullerian hormone
Brief summary
The main objective of this study is to assess the ovarian reserve of CF patients via measurement of AMH and AFC. Secondly, we aim to correlate between the ovarian reserve and demographic and clinical characteristics of these patients. Outcomes measured will be levels of AMH and AFC, as compared to standard means in the general population. There is no need for a control group in this study since the standardized means of AMH and AFC in the general population are a more accurate comparable measure, which is based on data collected from large-scale populations, and thus accounts for confounding age factor in a more complete manner than can be obtained via a control group (Almog et al., 2011, La Marca et al., 2012, Penzias et al., 2020).
Interventions
None listed
Sponsors
Hadassah Medical Organization
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Female patients diagnosed with CF according to genetic testing. * Age 18-45 years old. * Routinely attended the CF Center at Hadassah Medical Center.
Exclusion criteria
* Refusal to participate in the study. * Age under 18 or above 45. * Use of hormonal contraceptives (for the purpose of AFC).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AMH levels | 24 hours | Levels of Anti-Mullerian hormone |
| Antral follicular count | Through study completion, an average of 1 year. | Antral follicular count as assessed by ultrasound |
Countries
Israel
Contacts
Primary ContactKeren Marks-Garber, MD
Outcome results
None listed