Ischemic Stroke, Thrombosis
Conditions
Keywords
ischemic stroke, thrombolysis
Brief summary
This research is based on clinic treatment of intravenous thrombolysis for patients with acute ischemic stroke.By building up a database of these patients, the investigators aim to find some significance between groups by analyzing population information, clinical status and such for better evaluation and optimal treatment decision.
Detailed description
With the highest incidence rate,the population in northeast of China is severely tormented by stroke, especially ischemic stroke. The investigators lunch this project by building up a database of detailed information of patients that fits the criteria of intravenous thrombolysis therapy.Including biochemical markers,imaging and follow-up,investigators intend to analysis these data,find factors that contributes to better prognosis,so as to push forward the prevention and control work.
Interventions
None listed
Sponsors
Yi Yang
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Diagnosis of ischemic stroke causing measurable neurological deficit 2. Onset of symptoms \<4.5 h before treatment begins 3. Age ≥18 y
Exclusion criteria
1. Significant head trauma or prior stroke in the previous 3 mo 2. Symptoms suggest SAH 3. Arterial puncture at noncompressible site in previous 7 d 4. History of previous intracranial hemorrhage 5. Intracranial neoplasm, AVM, or aneurysm 6. Recent intracranial or intraspinal surgery 7. Elevated blood pressure (systolic \>185 mm Hg or diastolic \>110 mm Hg) 8. Active internal bleeding 9. Acute bleeding diathesis, including but not limited to 10. Platelet count \<100 000/mm3 11. Heparin received within 48 h resulting in abnormally elevated aPTT above the upper limit of normal 12. Current use of anticoagulant with INR \>1.7 or PT \>15 s 13. Current use of direct thrombin inhibitors or direct factor Xa inhibitors with elevated sensitive laboratory tests (eg, aPTT, INR, platelet count, ECT, TT, or appropriate factor Xa activity assays) 14. Blood glucose concentration \<50 mg/dL (2.7 mmol/L) 15. CT demonstrates multilobar infarction (hypodensity \>1/3 cerebral hemisphere) 16. Relative
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mRS score in 90 days | 90 days | Using mRS score to evaluate the effective of thrombolysis among different groups. |
| Stroke recurrence within 90 days | 90 days | Newly onset stroke that the time interval was less than 90 days from the original stroke event was considered as stroke recurrence. Ischemic stroke was defined as acute focal brain or retinal infarction. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular death in 1 year | 1 year | Death direct from ischemic stroke, hemorrhagic stroke, sudden cardiac death, acute myocardial infarction, heart failure, and other cardiovascular death including cardiac arrhythmia that unrelated to sudden cardiac death, pulmonary embolism, cardiovascular intervention (unrelated to acute MI), ruptured aortic aneurysm, or peripheral arterial disease). |
| Post-stroke disability in 1 year | 1 year | modified Rankin Scale(mRS)≥3 |
Countries
China
Contacts
Primary ContactYi Yang, MD，PhD
Backup ContactZhenni Guo, MD
Outcome results
None listed