Acute Respiratory Distress Syndrome, Chemical Injury, Chemicals; Intoxication, Distress Respiratory Syndrome, Medical Emergencies
Conditions
Keywords
CBRNE Defence, Acute Settings, Pre-Hospital Settings, Decontamination, Protection, Respiratory Insults, Treatments
Brief summary
Observation study measuring medical response in contaminated environment.
Detailed description
This is an ongoing multicentric observational study that aims to assess the medical response to chemical, biological, radiological, nuclear, explosive (cbrne) events during the last five (5) decades (i.e.: 1970-2020), and in any future cbrne attack that might occur within the next 15 years (i.e.: 2021-2036). Of note, the data collection will be performed retrospectively and after sites review ethic board (REB) approval.
Interventions
PROCEDUREClinical interventions performed in acute settings (contaminated environment)
Any clinical intervention performed on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic).
PROCEDUREProtection (clinician and patient)
As interrelated competence of the clinical intervention, any protection procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with.
PROCEDUREDecontamination (clinician and patient)
As interrelated competence of the clinical intervention and protection, any decontamination procedure and capability applied on the patient inflicted by at least one of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) weapons in acute settings (from the incident site up to his/her admission to the clean zone of a emergency room or its equivalent (ie.: walking clinic). Concerning the clinician, the protection implied for his/her own safety and for the patient to whom she/he was in closed/contact with. This crucial step is usually expected prior the patient's transfer into a clean zone like the emergency room or its equivalent.
Sponsors
Quebec Heart and Lung Institute, Quebec City, Canada
Sorbonne University
Medical Intelligence CBRNE inc.; Quebec City, Canada
Department of Intensive Care Medicine, Tokyo, Japan
Centre for Defence and Security Studies, University of Manitoba, Winnipeg, Canada
Biomedical Telematics Laboratory, Quebec Respiratory Health Research Network, Sherbrooke, Canada
Tokyo University
Tokyo Women's Medical University
University of Maryland, College Park
St. Justine's Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
i. a CBRNE attack caused at least one casualty who required the assistance of the participating health care system (e.g.: physicians, nurses, paramedics and other health-care specialists of a medical facility) during a medical extraction from the incident site until admission to a medical facility; ii. Patients are eligible if they were exposed to the CBRNE attack; iii. Medical information concerning the CBRNE exposures, even if partial, is accessible to health care professionals for the purposes of filling out the online case report form (eCRF); iv. Participants must be able to complete the online case report form in English; and v. The approval of an Ethics Review Board is obtained by each medical centre participant.
Exclusion criteria
A negative response to any of the inclusion criteria results in an exclusion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intervention and location | At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation). | The percentage of patients to whom the World Health Organization's healthcare guidelines were applied without any delay (i.e.: during a medical extraction/evacuation) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Contamination is under-control due to efficient protective measures applied during a medical extraction/evacuation | At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation). | The percentage of patients whose health condition remained stable during a medical extraction due to efficient WHO's protective measures applied |
| Contamination under-control due to efficient decontamination measures applied during a medical extraction/evacuation | At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation). | The percentage of patients whose health condition remained stable during a medical extraction due to efficient WHO's decontamination measures applied |
| Deterioration of the patient's health condition due to compromised means of protection | At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation). | The percentage of patients whose health condition deteriorate during a medical extraction due to the misuse of WHO's protective measures (e.g.: mask, suit, gloves, boots, etc). |
| Deterioration of the patient's health condition due to compromised means of decontamination | At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation). | The percentage of patients whose health condition deteriorated during a medical extraction due to the misuse of WHO's decontamination measures (e.g.: immediate (roughly) or/and thorough (specialized one)). |
Countries
Canada, Czechia, France, Japan, United Kingdom, United States
Outcome results
None listed