Persistent Critical Illness
Conditions
Keywords
Critical care, Metabolism, Nutrition, Propofol sedation, Hypophosphatemia, Refeeding syndrome, Insulin resistance, Malnutrition
Brief summary
The Corona Virus Disease-19 (COVID-19) pandemic has resulted in an overwhelming number of intensive care (ICU) patient admissions, generally for acute respiratory distress, often resulting in persistent critical illness (PCI). Little is known about their metabolic and nutritional characteristics compared to other non-COVID (non-CO) categories of patients. The aim is to compare the metabolic characteristics and gastro-intestinal function of the previously admitted non-CO and COVID persistent critically ill patients, and the adherence to the ICU nutrition protocol. Prospective observation study including two consecutive cohorts of PCI, defined by a prolonged mechanical ventilation requirement longer than 10days.
Detailed description
The metabolic and nutritional characteristics of the COVID-19 patients requiring prolonged ICU treatment compared to other non-COVID (non-CO) categories of patients remain poorly described. The aim was to compare the metabolic characteristics of the previously admitted non-CO and COVID PCI patients. Prospective observation study including two consecutive cohorts of PCI, defined as requiring a mechanical ventilation for \>10 days. The comparative cohort is the first patient cohort previously registered as NCT03938961. Variables: demographic data, severity score (SAPS2, organ failure (SOFA) scores), Nutrition Risk Screening (NRS) score, C-reactive protein (CRP), blood phosphate. Nutritional variables: energy intake (detail of protein, lipids, glucose), fasting time, feeding route, prealbumin values, bowel activity, insulin requirements Outcome: length of mechanical ventilation, ICU and hospital stay and outcome. Descriptive statistics
Interventions
OTHERNutrition therapy according to ICU protocol
The study aims a verifying adherence to the ICU nutrition protocol
Sponsors
Centre Hospitalier Universitaire Vaudois
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Inclusion criteria
* adult patients requiring more than 10 days on mechanical ventilation
Exclusion criteria
* patients refusing use of their coded data * admission for brain injury or after cardiac arrest * admission for major burns \>20% body surface area (BSA)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy balance | up to 30 days | Delta between energy delivery and prescription |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Feeding route and time to feeding | up to 30 days | Proportion of days on enteral, parenteral, combined, oral feeding or fasting |
| Hypophosphataemia | up to 30 days | Number of blood phosphate values \<0.8 mmol/l |
| Insulin resistance | up to 30 days | Quantity of insulin required to maintain blood glucose with ICU targets |
| Bowel activity | up to 30 days | Frequency of diarrhea and constipation |
| Length of ICU and hospital stay | up to 3 months | length in days |
Countries
Switzerland
Outcome results
None listed