Healing Wound
Conditions
Brief summary
Ziziphus honey can improve bone healing at extracted tooth sockets in humans by increasing salivary levels of bone markers, OPN and BMP-2.
Detailed description
objectives of study: To study the effects of ziziphus honey on bone healing of extracted tooth socket in humans by comparing 1) Levels of BMP-2 and OPN in experimental and control groups at different intervals and 2) By radiographically measuring RBD of extraction sockets in experimental and control groups. Aim of study: Post extraction ridge resorption is a major concern for future tooth prosthesis or implant placement. Honey can possibly help to improve bone healing and minimize ridge resorption after extractions. Materials and Methods: Randomized controlled trial with simple random sampling of healthy individuals will be done. Total number of 30 participants will be equally divided into experimental group and control group. After tooth extractions in both groups, ziziphus honey will be injected into extracted sockets of experimental group while control group will be left as it is. Levels of BMP-2 and OPN will be tested in saliva through ELISA technique at day 0, 3 and 7 of tooth extraction and RBD will be measured on periapical radiographs at day 3, 21 and 40 in both groups. Keywords: Bone morphogenetic protein-2 (BMP-2), Osteopontin (OPN), Relative bone density (RBD), Enzyme linked immunosorbent assay (ELISA).
Interventions
DRUGziziphus honey
ziziphus honey obtained form ziziphus spina-christi trees also called sidr tree
Sponsors
Postgraduate Medical Institute, Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Masking description
Participants were not aware of the intervention used
Intervention model description
randomized controlled trial with simple random sampling technique
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy patients of either gender with adult age 2. No known hypersensitivity to honey. 3. Permanent maxillary or mandibular molars (first or second molars)
Exclusion criteria
1. History of radiotherapy or chemotherapy 2. Diabetic and hypertensive patients. 3. Pregnant and lactating females. 4. Smoking or consumption of alcohol 5. Bone conditions like osteoporosis etc. 6. Patients on oral contraceptives or steroid therapy 7. Subjects taking antibiotics or NSAIDS within one week.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relative bone density | 40 days | bone quality confirmed on periapical radiographs in both groups |
| levels of BMP-2 | 1 week | bone morphogenetic protein-2 levels to access amount of bone healing |
| levels of OPN | 1 week | Osteopontin levels to access amount of bone healing |
Countries
Pakistan
Outcome results
None listed