Parkinson Disease
Conditions
Brief summary
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research. Thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. The specific short-term objectives are: 1. To establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing. 2. To demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.
Interventions
We are assessing several cognitive domains and have made minor adaptations (reducing the total number of trials or lengthening response windows) to several standard neuropsychology tests including measures of executive function, working memory, visuospatial function, declarative memory, reward processing, response inhibition. Overall, the tests we use follow a standard set-up: participants are shown stimuli on the screen and are asked to provide a response using either a keyboard or a mouse, based on a specific set of instructions. We always provide a detailed set of on-screen instructions and a practice phase. In some cases, information about performance is provided in the form of points, in other cases, none is provided.
Sponsors
McGill University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
45 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosis of Parkinson's disease by neurologist or healthy individual with no diagnosis of any neurological illness
Exclusion criteria
* Psychotic spectrum disorders, active uncontrolled depression, advanced dementia (i.e. needing assistance with daily activities such as dressing or bathing), major stroke, major head injury, epilepsy requiring anti-seizure medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Completion rate of cognitive test set (feasibility) | Measured once, as this is a cross-sectional study (time to complete cognitive tests is estimated to be 1.5 hours) | Proportion of registered participants who complete all the cognitive testing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reliability of web-based vs in-person reward processing testing | Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart | Intraclass correlation coefficient for web-based vs. in-person performance on the probabilistic reward task will be computed |
| Reliability of web-based vs in-person working memory testing (n-back test) | Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart | Intraclass correlation coefficient for web-based vs. in-person performance on the n-back test will be computed |
| Reliability of web-based vs in-person executive function testing (Stroop test performance) | Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart | Intraclass correlation coefficient for web-based vs. in-person performance on the Stroop test will be computed |
| Reliability of web-based vs in-person visuospatial function testing (Trail making test performance) | Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart | Intraclass correlation coefficient for web-based vs. in-person performance on the Trail making test will be computed |
| Reliability of web-based vs in-person declarative memory testing (recognition memory) | Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart | Intraclass correlation coefficient for web-based vs. in-person performance on the image recognition test will be computed |
Countries
Canada
Contacts
Primary ContactMadeleine Sharp, MD
Outcome results
None listed