Respiratory Insufficiency
Conditions
Brief summary
Most patients in ICU are treated with a combination of analgesics and sedatives in most cases. Due to the different mechanism of different sedative and analgesic drugs, different antagonistic or synergistic effects may occur when combined with drugs, resulting in different clinical effects, especially significant effects on ventilators for patients with assisted breathing. Therefore, this study hopes to compare the effects of different sedative and analgesic drug combinations on the duration of mechanical ventilation for patients with ventilators, so as to guide the clinical adoption of a more reasonable sedative and analgesic scheme.
Interventions
The patients in this group will be administered with fentanyl and propofol
DRUGfentanyl and dexmedetomindine
The patients in this group will be administered with fentanyl and dexmedetomindine
The patients in this group will be administered with butorphanol and propofol
DRUGButorphanol and dexmedetomindine
The patients in this group will be administered with butorphanol and dexmedetomindine
Sponsors
The Affiliated Hospital of Qingdao University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults who are treated with sedation and analgesia for invasive mechanical ventilation
Exclusion criteria
* they have baseline severe cognitive impairment; were pregnant or breast-feeding; were blind, deaf ; had second-degree or third-degree heart block or bradycardia requiring intervention; had an allergy to the experimental drugs; had an indication for benzodiazepines; were anticipated to have immediate discontinuation of mechanical ventilation; were expected to have neuromuscular blockade for more than 48 hours; were in a moribund state; or had received mechanical ventilation for more than 96 hours before meeting all inclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator-free days at 28 days | at 28 days |
Contacts
Primary ContactJinyan Xing, Dr
Outcome results
None listed