Arrhythmogenic Right Ventricular Cardiomyopathy
Conditions
Keywords
ARVC, Athlete's heart, exercise, CMR, RV contractile reserve
Brief summary
Prospective, nonrandomized, single-center, comparative study to define if right ventricular (RV) contractile reserve assessed by exercise CMR helps to improve the differential diagnosis between pathological and physiological remodeling of the RV; ie. arrhythmogenic right ventricular cardiomyopathy (ARVC) and athlete's heart.
Detailed description
Comparison of the RV contractile reserve in 4 groups of patients: Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients; endurance athletes with a dilated RV, endurance athletes with normal RV, untrained subject with normal RV. Patients will come to the hospital for 3 visits (3 half days): * Visit 1: clinical evaluation, rest ECG, rest echocardiography, cardio-pulmonary exercise test. * Visit 2: exercise echocardiography, holter ECG monitor (48 yours) * Visit 3: rest CMR and exercise CMR (ergocycle)
Interventions
OTHERCardiac exercises and tests
Rest ECG, rest echocardiography, cardio-pulmonary exercise test, exercise echocardiography, holter ECG monitor (48 yours), rest CMR, exercise CMR (ergocycle)
Sponsors
Rennes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Men or women aged 18 years and older, * patients with confirmed ARVC, but with no major RV dysfunction (RVEF \>40%) * endurance athletes with dilated RV * endurance athletes with non-dilated RV * untrained healthy subjects with non-dilated RV * who signed a written free and informed consent:
Exclusion criteria
* Patients with other cardiovascular disease; * Contra-indication to CMR (in particular presence of a non-CMR compatible implantable cardiac defibrillator); * Patients with permanent supraventricular arrhythmia; * Patients unable to perform an exercise test on an ergocycle; * Person subject to legal protection (safeguard justice, trusteeship and guardianship) and persons deprived of liberty
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evolution of right ventricular ejection fraction (RVEF) assessed with CMR during exercise | Through study completion, an average of 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Evolution of Tricuspid annular plane systolic excursion (TAPSE) during exercise | Through study completion, an average of 1 month |
| Evolution of S' tricuspid wave during exercise | Through study completion, an average of 1 month |
| Evolution of RV fractional area during exercise | Through study completion, an average of 1 month |
| Evolution of free wall RV strain during exercise | Through study completion, an average of 1 month |
Countries
France
Contacts
Primary ContactFrédéric SCHNELL, MD-PhD
Outcome results
None listed