Anxiety Depression Disorder
Conditions
Keywords
Vetiver oil, Aromatherapy, Anxiety, Depression
Brief summary
In this study, subjects with depression/anxiety inhaled the essential oil, which contained sedative, soothing, and relaxing active ingredients to stimulate the olfactory nerve. The essential oil further transmitted to the limbic system that controls emotions in the brain, and then affected the human's mood. The natural aroma can not only awaken the limbic system's memory of aroma but also reflect the subconscious area of the brain, with physiological changes (such as controlling blood pressure, breathing, heartbeat, stress changes, memory, and hormonal coordination.) This study monitors the subject's autonomic nerve parameters before and after aromatherapy to obtain the olfactory cerebral nervous system to convey the message. When the study finishes, we expected to help the subject to relax and soothe the mind.
Detailed description
Subjects receive three times 30 mins aromatherapy of Limon or Vetiver essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.
Interventions
DEVICELimon essential oil aromatherapy
Subjects receive three times 30 mins aromatherapy of Limon essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.
DEVICEVetiver essential oil aromatherapy
Subjects receive three times 30 mins aromatherapy of vetiver essential oil per time for the month. Anthropometric measurements such as blood pressure (systolic blood pressure \[SBP\] and diastolic blood pressure \[DBP\]), autonomic nerve parameters including a. SDNN (standard deviation of all normal to normal intervals index); b. HRV（heart rate variability）; c. LF（0.04-0.15 Hz）and HF（0.15-0.4 Hz）were measured every week. PSQI（Pittsburgh sleep quality index）and HADS (Hospital Anxiety and Depression Scale) were measured initial and ten ends.
Sponsors
Chung Shan Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Depressed/anxious people (diagnosed as a single episode of major depression, recurrence of major depression, mild depression, panic disorder, and anxiety.) Those diagnosed with symptoms of depression, and anxiety related to stress adjustment disorder, and willing to cooperate with the study. 2. Age 20-65 years old
Exclusion criteria
1. an alcoholic 2. Uncontrolled diabetes 3. Those who have had a stroke in the last year 4. Pregnant and lactating women 5. People with liver or heart disease 6. Arrhythmia or those with a heart rhythm regulator 7. Those whose heart has already been fitted with a cardiac catheter stent 8. Those who have used central nervous system stimulants (regardless of the length of time) 9. Those who are allergic to essential oils 10. Those who have used aromatherapy within a month 11. Subjects request to withdraw from the trial 12. The host feels unsuitable to continue the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The aromatherapy measure autonomic nerve parameter SDNN (standard deviation of all normal to normal intervals index) | one month | — |
| The measure blood pressure (SBP and DBP) | one month | values change of systolic and diastolic BPs |
Countries
Taiwan
Contacts
Primary ContactYou-Cheng Mr Shen, Ph.D.
Backup ContactChang-Yao Mr TSAO, MD/PhD.
Outcome results
None listed