Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery and Anesthetic Depth

Comparison of Desflurane and Sevoflurane Minimal Flow Anesthesia on Recovery Parameters and Anesthetic Depth: a Randomized Prospective Study

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05024084

Enrollment

130

Registered

2021-08-27

Start date

2021-09-05

Completion date

2021-10-01

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

general anesthesia, low flow anesthesia, sevoflurane, desflurane

Brief summary

Minimal flow anesthesia has economic and environmental advantages in addition to providing earlier recovery following general anesthesia. There is a paucity of data concerning the effect of minimal flow anesthesia (fresh gas flow \<0,5 l/min) on recovery parameters. The primary objective of this study is to compare the recovery parameters of desflurane and sevoflurane in minimal flow anesthesia while the secondary objective is to compare the effect of these agents on anesthetic depth using bispectral index.

Interventions

PROCEDUREMinimal flow anesthesia (fresh gas flow <0.5 l/min) using Sevoflurane

Sevoflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min

PROCEDUREMinimal flow anesthesia (fresh gas flow <0.5 l/min) using Desflurane

Desflurane will be used for the maintenance of general anesthesia which will be carried out using a fresh gas flow of less than 0,5 l/min

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Ages between 18 and 65 * Patients undergoing elective surgery under general anesthesia * Patients with an American Society of Anesthesiologists Classification I or II

Exclusion criteria

* Patient refusal * Emergency surgery * Patients with a contraindication for minimal flow anesthesia * Uncontrolled diabetes mellitus * History of serious systemic disease (cardiac, pulmonary, hepatic) * Utilization of another analgesic technique such as central or peripheral nerve blocks

Design outcomes

Primary

Measure	Time frame	Description
Time until eye opening	Up to 20 minutes after discontinuation of the volatile anesthetic	Time interval between discontinuation of the volatile anesthetics and eye opening with verbal command
Time until transfer readiness	Up to 45 minutes after discontinuation of the volatile anesthetic	Time interval between discontinuation of the volatile anesthetics and Aldrete score reaching 9 or greater
Time until extubation	Up to 10 minutes after discontinuation of the volatile anesthetic	Time interval between discontinuation of the volatile anesthetics and removal of the endotracheal tube

Secondary

Measure	Time frame	Description
Anesthetic depth provided by the volatile anesthetic	Change in Bispectral Index values at 5, 10, 15, 30, 60 and 120 minutes	Anesthetic depth as measured by Bispectral Index

Countries

Turkey (Türkiye)

Contacts

Primary ContactBaturay K Kazbek, Ass. Prof.

bkkazbek@gmail.com+903122044000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026