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Efficacy and Safety of Immunotherapy in Non-small Cell Lung Cancer With Uncommon Histological Type

Evaluation of the Efficacy of Immunotherapy in Uncommon Pathological Types of Lung Cancer

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05023837
Acronym
Esporta
Enrollment
40
Registered
2021-08-27
Start date
2018-03-02
Completion date
2021-08-03
Last updated
2022-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uncommon Pathological Types of Lung Cancer

Keywords

Uncommon pathological types of lung cancer, Immune checkpoint inhibitor

Brief summary

This study was designed to explore the efficacy and safety of immune checkpoint inhibitor for advanced uncommon pathological types of lung cancer whether or not it is accompanied by a driver mutationin the real world. Through retrospective collection of clinical data of patients with uncommon pathological types of lung cancer.The patients who are treated with immunosuppressive agents are screened out, and they are divided into immune combination therapy or immune monotherapy, and further evaluate whether there is a difference in efficacy between the two.

Detailed description

This is a research project involving patients in Medical Oncology Department of Affiliated Cancer Hospital of Xiangya School of Medicine Central South University. Retrospective study of 40 patients with advanced uncommon pathological types of lung cancer and observe the efficacy and safety of immune checkpoint inhibitor regimen in the real world. The patients who are treated with immunosuppressive agents are screened out, and they are divided into immune combination therapy or immune monotherapy, and further evaluate whether there is a difference in efficacy between the two. Statistical analysis is used to compare the differences between the two treatments, so that patients can better choose treatment strategies.

Interventions

DRUGPembrolizumab 100 MG Injection

Pembrolizumab iv 200mg q21d

Sponsors

Hunan Province Tumor Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* 18,Advanced uncommon pathological types of lung cancer by histopathology whether or not it is accompanied by a driver mutation Treatment Plan is pembrolizumab 200mg iv q21d

Exclusion criteria

\- Patients received antitumor treatment before Patients with contraindication of chemotherapy Pregnant or breast feeding women

Design outcomes

Primary

MeasureTime frameDescription
PFSmay 2019- may 2021progression survival time

Secondary

MeasureTime frameDescription
OSmay 2019- may 2021over survival time

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 11, 2026