Neonatal Sepsis
Conditions
Keywords
Early-onset neonatal sepsis, Presepsin, Clinical scoring, Early predictors, Blood culture
Brief summary
124 neonates aged ≤7 days with suspected EOS were clinically evaluated using SNAP-II and gave blood samples for BC, total leucocytic count (TLC), lymphocytic and neutrophil count, and ELISA estimation of serum levels of PSP, procalcitonin (PCT), and tumor necrosis factor-α (TNF-α). Enrolled neonates were categorized as Confirmed EOS: neonates with evident clinical sepsis manifestations and positive BC, Suspected EOS: neonates with evident clinical sepsis manifestations but had negative BC and No EOS included neonates free of evident clinical sepsis manifestations, had negative BC and showed no deterioration till 72-hr after admission.
Interventions
DIAGNOSTIC_TESTSerum Presepsin
Estimation of Serum Presepsin at time of admission
Sponsors
Tanta University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
1 Days to 7 Days
Healthy volunteers
No
Inclusion criteria
* included gestational age (GA) of 28-41 weeks and 5-min APGAR score of ≥7, and neonatal age of \<7 days
Exclusion criteria
* including small for gestational age, presence of a chromosomal abnormality, multiple congenital anomalies, genetic syndromes, history of premature rupture of membranes, chorioamnionitis, neonatal asphyxia, and missed inclusion criterion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| prediction of neonatal outcome | one week | Ability of Serum Presepsin to disseminate neonates with confirmed EOS |
Countries
Egypt
Outcome results
None listed