Whole Egg Intake and Choline Concentration in the Aging Brain

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05021211

Enrollment

Registered

2021-08-25

Start date

2021-06-01

Completion date

2024-05-01

Last updated

2024-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease

Keywords

Choline, Egg Consumption, Alzheimer Disease, Cognitive Impairment, Dementia

Brief summary

By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition.

Detailed description

Participants will come to the research center for 2 different visits. Visit 1 will include anthropometric measurements, surveys, and a cognitive test. Approximately 7-10 days after visit 1, participants will come back to the research center for visit 2. At visit 2, participants will return surveys and a MRI scan will be performed to measure brain choline status. Potential participants need to be located within the Kansas City metro area.

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

60 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged between 60 - 85 years of age * Good general health with no concomitant diseases * Cognitively normal as defined as Mini-mental state examination (MMSE) score ≥ 25 * BMI range: 20 - 40 kg/m2

Exclusion criteria

* Presence of central neurological disease (e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer's, Parkinson's) * Prior major head trauma with loss of consciousness * Presence of active unstable and life-threatening illness (e.g., cancer) * Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score \> 6) * Presence of diabetes mellitus or use of anti-diabetic agents * Use of psychoactive and investigational medications * Use of hormone replacement therapy * Tobacco smokers * Subjects with MRI contraindications

Design outcomes

Primary

Measure	Time frame	Description
Association Between Whole Egg Intake and Cerebral Choline	Baseline	The investigators will recruit a variety of whole egg consumers. Egg consumption will be validated with a 7-day food record 1 week before the MRI. Cerebral choline levels are measured by magnetic resonance spectroscopy (MRS)
Association Between Cerebral Choline and Cognition	Baseline	The investigators will test the association between cerebral choline as measured by MRS and cognition. Cognition will be measured by the NIH ToolBox cognitive battery.

Countries

United States

Outcome results