Osteoarthritis of the Knee, Sarcopenia
Conditions
Brief summary
The aim of this thesis; To define sarcopenia in knee osteoarthritis with ultrasonography and to evaluate changes in muscle structure in sarcopenia after isokinetic exercise application ultrasonographically. The investigators will evaluate the effect of isokinetic exercise therapy in sarcopenic patients with knee osteoarthritis with VAS (Visual Analog Scale) and WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index). Then, the hand grip strength will be evaluated with a dynamometer, and its effects on physical performance will be evaluated by 6 meters walking and chair rising tests.
Detailed description
Among the 45-65 age group who applied to Mustafa Kemal University Faculty of Medicine, Physical Medicine and Rehabilitation outpatient clinic, 30 female patients diagnosed with knee osteoarthritis (stage 1-2-3) and sarcopenia together, and 30 individuals without osteoarthritis and sarcopenia will be included in the study as the control group.Patients with knee osteoarthritis who have been diagnosed with sarcopenia by ultrasonography will be Group I, and the control group without osteoarthritis and sarcopenia will be Group II.30 patients in Group I will be given an exercise program with isokinetic dynamometer for both knees, 30 minutes of TENS (transcutaneous electrical nerve stimulation), 20 minutes of hot packs, and home exercise program will be given lower extremity strengthening for a total of 6 weeks (18 sessions), 3 sessions per week.A diet program (protein, mineral, vitamin D supplemented) will also be given to these patients. The control group, which is group II, will be offered a home exercise program and diet for lower extremity strengthening only.Those with a history of complicated Diabetes Mellitus, Severe Coronary Artery Disease / Congestive Heart Failure, severe Liver Failure, neuromuscular disease, previous lower extremity surgery, rheumatological disease, use of walking aids will not be included in the study.The patient group and control group pre-treatment (week 0) and post-treatment (week 6) clinical; hand grip strength will be evaluated with Jamar dynamometer, walking speed will be evaluated with 6 meters walking test, lower extremity endurance will be evaluated with chair rise test, functional assessment of knee osteoarthritis will be evaluated by WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and pain assessment will be evaluated by VAS (Visual Analogue scale) will be evaluated with a pain questionnaire.In addition, changes in the Rectus Femoris and Vastus Lateralis muscle architecture on the dominant side of the patients; muscle thickness, fascicle length, echogenicity, pennation angle and cross-sectional area measurements will be evaluated before treatment (0 weeks) and after treatment (6 weeks) by ultrasonography.
Interventions
OTHERKnee strengthening exercises with isokinetic dynamometer
18 sessions of strengthening exercises around the knee with an isokinetic dynamometer 3 days a week
OTHERStrengthening around the knees with home exercise programe
18 sessions of strengthening exercises for the muscles around the knee at home, 3 days a week
Sponsors
Sema Dağcı
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Among the 45-65 age group, 30 female patients diagnosed with knee osteoarthritis (Stage 1-2-3) and sarcopenia together * Among the 45-65 age group, 30 females without osteoarthritis and sarcopenia will be included in the study as the control group.
Exclusion criteria
* Diabetes Mellitus, * Severe Coronary Artery Disease / Congestive Heart Failure, * Severe Liver Failure, * Neuromuscular disease, * Lower extremity surgery, * Rheumatological disease, * Those who use walking aids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle architecture | Six weeks | Determination of muscle architecture change with ultrasonography after isokinetic exercise |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Walking speed | Six weeks | Evaluation of the change in walking speed with isokinetic exercise |
| Hand grip strength | Six weeks | Evaluating the effect of isokinetic exercise on hand grip strength with a hand dynamometer |
| Knee pain | Six weeks | The effect of isokinetic exercise with VAS (visual analog scale) on pain level |
| Functional status | Six weeks | Effect of isokinetic exercise on activities of daily living with WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) |
| Time to get out of the chair | Six weeks | Evaluation of the change in sitting time by standing up from the chair 5 times with isokinetic exercise |
Countries
Turkey (Türkiye)
Contacts
Primary ContactSema Dagci, M.D.
Outcome results
None listed