Comparison of Postoperative QoR-15 Scores Between Sevoflurane and Remimazolam

Comparison of Quality of Recovery (QoR)-15 Scores According to the Use of Anesthetics During General Anesthesia in the Cervical Spine Surgery Patients: Sevoflurane vs. Remimazolam

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05019222

Enrollment

Registered

2021-08-24

Start date

2021-09-26

Completion date

2022-08-14

Last updated

2023-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Cervical Discectomy and Fusion (ACDF) Surgery

Keywords

Cervical surgery, Quality of Recovery, Remimazolam, sevoflurane

Brief summary

The purpose of the study is to compare the quality of recovery (QoR)-15 scores according to the use of maintenance anesthetics in the cervical spine surgery. Total intravenous anesthesia (TIVA) have been known to help reducing risks of postoperative nausea/vomiting and malignant hyperthermia. However, it is still not enough to explain which is better between TIVA or inhalation anesthesia. In particular, there is no study to investigate overall postoperative functional recovery via QoR-15 in patients receiving TIVA with remimazolam. The hypothesis of the investigators study is that, in patients with cervical spine surgery, total intravenous anesthesia based on remimazolam can improve the the quality of recovery compared to inhalation anesthesia based on sevoflurane.

Interventions

DRUGSevoflurane based inhalation anesthesia

Sevoflurane group will be inducted with bolus of propofol 1% and maintained with sevofulrane as inhalation and TCI Minto model of remifentanil for general anesthesia.

DRUGRemimazolam based total intravenous anesthesia

Remimazolam group will be inducted with remiamazolam at 6 mg/kg/h and maintained with remimazolam at 0.5-1.5 mg/kg/h and TCI Minto model of remifentanil for general anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Adult patients who aged 20-70 years * ASA-PS: 1-3 * BMI \< 30 * Anterior cervical discectomy and fusion surgery

Exclusion criteria

* Tolerance or hypersensitivity to benzodiazepine * Dependence or addiction to psychotropic drugs or alcohol * Pregnant women, subjects who lack the ability to make decisions and susceptible to voluntary participation decisions

Design outcomes

Primary

Measure	Time frame	Description
The difference between two groups (sevoflurane vs. remimazolam) in QoR-15 scores	postoperative day 1	The difference of scores in the Quality of Recovery (QoR)-15 survey on POD 1 Total 0-150, 0 (minimum), 150 (maximum), Higher scores means better.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026