Electroacupuncture, Lung Injury, Ventilator Induced
Conditions
Keywords
Electroacupuncture, Lung protection, ventilator induced lung injury
Brief summary
Objective to investigate the protective effect of preoperative electroacupuncture on lung function in patients with mechanical ventilation for more than 2 hours under general anesthesia
Detailed description
Randomized parallel control study. From September 1, 2021 to December 31, 2022, patients with mechanical ventilation time more than 2 hours will be randomly divided into electroacupuncture pretreatment group and blank control group. The blood gas index, ventilator parameters and serum inflammatory factor concentration of patients will be evaluated to evaluate whether electroacupuncture has protective effect on lung function of patients with mechanical ventilation.
Interventions
OTHERelectroacupuncture
In the electroacupuncture group, acupoints of Lieque (+), Chize (-), Sanyinjiao (-), Zusanli (+), Tanzhong (+) and Yutang (-) will be selected for electrical stimulation. Density wave will be selected, and the current intensity should be tolerated by the patients. Conventional anesthesia operation could be started after the connection of electroacupuncture, and acupuncture point stimulation will be stopped 30min later.
Sponsors
Lingling Ding
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing general anesthesia in our hospital; * Ages 18-60; * American Society of Anesthesiologists (ASA) grade ⅱ \ III , no severe respiratory, circulation, liver, kidney, coagulation function abnormalities; * Expected duration of operation \>2h; * Surgical grade 2-4; * No serious lung infection and lung disease; * Body mass index (BMI) 18\ 30 kg/m2; There are no contraindications for electroacupuncture stimulation.
Exclusion criteria
* Patients with severe circulatory or other system dysfunction; * Patients with pulmonary and one-lung ventilation; * Unwilling to cooperate with the patient; * Patients with low compliance.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxygenation index | Before anesthesia | record oxygenation index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sedation score (Ramsay) | during anesthesia recovery period | Assess the quality of recovery during recovery |
| restfulness score (DRS) | during anesthesia recovery period | Assess the quality of recovery during recovery |
| visual analogue scale (VAS) | during anesthesia recovery period | Assess the quality of recovery during recovery |
| Length of stay | 1 week after discharge, the patient's length of stay will be recorded through medical record system | Assess the quality of postoperative recovery |
| postoperative time in hospital | 1 week after discharge, the patient's postoperative time in hospital will be recorded through medical record system | Assess the quality of postoperative recovery |
| postoperative complications of major organs | Major organ complications during hospitalization，assessed up to 30 days after surgery | Assess the quality of postoperative recovery |
| mortality within 30 days | mortality within 30 days will be recorded | Assess the quality of postoperative recovery |
| Postoperative comfort score | during anesthesia recovery period | Assess the quality of recovery during recovery |
| Expression of IL-1β in serum | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-1β in serum will be detected by flow cytometry | The perioperative inflammation level will be assessed |
| Expression of IL-10 in serum | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-10 in serum will be detected by flow cytometry | The perioperative inflammation level will be assessed |
| Mean arterial pressure | Before anesthesia ,2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | Intraoperative vital signs will be recorded |
| heart rate | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | Intraoperative vital signs will be recorded |
| BIS | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | Intraoperative vital signs will be recorded |
| extubation time | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | Intraoperative vital signs will be recorded |
| anesthesia dosage | Before anesthesia , 2 hours after tracheal intubation , and 5minutes after tracheal intubation removal | Intraoperative vital signs will be recorded |
| Expression of IL-18 in serum | Before anesthetic induction the radial artery blood samples will be collected, and the expressions of IL-18 in serum will be detected by flow cytometry | The perioperative inflammation level will be assessed |
Contacts
Primary ContactLingling Ding, Doctor
Backup ContactJiaqi Ning, bachelor
Outcome results
None listed