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Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05017896
Enrollment
242
Registered
2021-08-24
Start date
2021-09-30
Completion date
2023-02-28
Last updated
2021-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Aneurysm, Dissecting

Brief summary

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Interventions

DIAGNOSTIC_TESTNormal CT Renal Perfusion imaging indexes

A CT imaging which indicates the status of renal perfusion is normal.

DIAGNOSTIC_TESTLow CT Renal Perfusion imaging indexes

A CT imaging which indicates the status of renal perfusion is low.

Sponsors

Qilu Hospital of Shandong University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

1. 18-70 years old 2. Acute type A aortic dissection diagnosed by CT angiography 3. Sign informed consent

Exclusion criteria

1. History of chronic kidney disease 2. History of cardiovascular operation 3. Acute kidney injury has occurred before operation 4. Pregnancy status

Design outcomes

Primary

MeasureTime frameDescription
Acute kidney injury after operationFrom date of operation until the date of acute kidney injury or date of death from any cause, whichever came first, assessed up to 30 days.Yes; No

Contacts

Primary ContactXin Zhao
zhaoxin3617@163.com+8618560086772

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026