Cerebral Palsy, Lower Urinary Tract Symptoms
Conditions
Keywords
cerebral palsy, lower urinary tract symptoms, incontinence, uroflow measurement
Brief summary
Until now, the use of invasive urodynamics with use of catheters is still the gold standard for lower urinary tract evaluation in subjects with CP. This suggests a psychological and physical impact of invasive urodynamics in subjects with CP and further demonstrates the need to avoid standard use of invasive urodynamics in children and adults with CP. The current study will evaluate usefulness of uroflowmetry, correlation between uroflowmetry parameters and different lower urinary tract symptoms will be investigated. Secondly, results of uroflowmetry indicating possible vulnerability of the upper urinary tract will be defined.
Detailed description
A cross-sectional case-control study comparing children with CP and LUTS and children with CP without LUTS will be conducted with the primary objective to investigate correlation between uroflowmetry parameters and different LUTS. Children will be evaluated with uroflowmetry and subsequent post void residual measurement and the validated vancouver symptom score for dysfunctional elimination syndrome.
Interventions
DEVICEuroflow measurement
Non-invasive urodynamic measurement wireless uroflowmeter UROCAP™ IV, Goby System Laborie
DEVICEBladder ultrasound
Ultrasound of post void residual urine bladderscan CUBEscan BioCon 700
Sponsors
University Ghent
University Hospital, Ghent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Children will be randomised in two groups, with evaluation with a standard toilet seat or a toilet seat with decreased hip angle.
Eligibility
Sex/Gender
ALL
Age
5 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of cerebral palsy * Dutch or French speaking child and parent
Exclusion criteria
* History of urological surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amount of pathological uroflow patterns - Qualitative assessment | During cross-sectional testing | Interpretation by pediatric urologist following ICCS classification Measured during uroflowmetry |
| Amount of pathological uroflow patterns - Quantitative assessment | During cross-sectional testing | Interpretation using Flow index methodology Measured during uroflowmetry |
| Maximal flow | During cross-sectional testing | Measured during uroflowmetry Qmax (mililitres/seconds |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Influencing factors for uroflow measurement | During cross-sectional testing | * Functional impairment of the child * hip angle * Vancouver symptom score for dysfunctional elimination syndrome |
| Voided volume | During cross-sectional testing | Measured during uroflowmetry mililitres Percentage of expected bladder capacity |
| Post void residual urine | During cross-sectional testing | Measured with CUBEscan BioCon 700 mililiters Percentage of voided volume |
Countries
Belgium
Outcome results
None listed