Preterm
Conditions
Brief summary
Establish a clinical diagnosis and treatment and long-term follow-up database of preterm infants, and analyze the effects of prenatal factors (including genetic characteristics, maternal diseases, etc.), postnatal diagnosis and treatment measures and family maintenance environment after discharge on preterm infant mortality and major diseases in the near and long term.
Detailed description
As an increasing large group, the long-term quality of life and health status of preterm infants have become a very important public health problem in China. This cohort study is a single center clinical cohort study. By collecting the clinical diagnosis, treatment and follow-up data of preterm infants admitted to the neonatal department of our hospital for 3 consecutive years (about 1200 cases), and following them for 18 years, a relatively complete resource database for the long-term health and development of preterm infants is established. The effects of perinatal factors, diagnosis and treatment methods and family rearing environment on the survival rate, neurointelligence development, chronic metabolic diseases and respiratory diseases of preterm infants were analyzed. It provides a basis for further improving the diagnosis and treatment plan, exploring potential therapeutic targets and establishing prediction models.
Interventions
DIAGNOSTIC_TESTGriffiths development scales
Griffiths development scales Chinese Edition (gds-c) was used to evaluate the development levels of children up to 6 years and WISC for children more than 6 years.
Sponsors
Shanghai Children's Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Days to 4 Months
Healthy volunteers
No
Inclusion criteria
1. Live born newborns with gestational age ≤ 36 + 6 weeks 2. Transfer to the neonatal ward of Shanghai Children's medical center within 24 hours after birth 3. Those who have lived in Shanghai for more than 1 year and plan to live in Shanghai for a long time. Parents voluntarily participated in the study and signed informed consent
Exclusion criteria
1. Premature infants: termination of treatment due to family factors (non-disease reasons) and hospitalization time ≤ 2 weeks 2. Major congenital malformations 3. Parents refuse to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neural development at 1 year old | 1 year | Taking Griffiths development scales Chinese Edition test for all the participants. |
| neural development at 2 years old | 2 years | Taking Griffiths development scales Chinese Edition test for partial participants. |
| neural development at 6 years old | 6 years | Taking Wechsler Intelligence Scale for participants. |
| Growth and neural development at 12 years old | 12 years | Taking Wechsler Intelligence Scale for participants. |
| Growth and neural development at 18 years old | 18 years | Taking Wechsler Intelligence Scale for participants. |
Countries
China
Contacts
Primary ContactShumei Dong, master
Outcome results
None listed