Kidney Transplantation
Conditions
Brief summary
Assessment of changes of renal hemodynamics by multiparametric MRI after closure of AVF access.
Interventions
DIAGNOSTIC_TESTEchocardiography and MRI
Echocardiography and renal MRI before and after fistula closure
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Written informed consent * Age \> 18 years * Patients wishing to close the fistula and planned for surgical fistula closure * eGFR CKD EPI ≥ 45 ml/min/1.73m2 at one year post transplantation * Stable eGFR within the past 6 months * Controlled blood pressure
Exclusion criteria
* Kidney Transplantation \< 12 months before fistula closure * Proteinuria \> 500mg/d * Presence of donor specific antibodies * Rejection within the past 6 months * BK virus replication within the past 3 months * Cardiac pacemaker, which is not compatible with MRI * Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment of changes in renal hemodynamics by multiparametric MRI after closure of AVF access | evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure | Assessing changes in renal perfusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between AVF access flow and changes as assessed during pneumatic fistula compression with changes in renal hemodynamics after fistula closure | evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure | Correlation between AVF access flow and changes as assessed during pneumatic fistula compression with changes in renal hemodynamics after fistula closure |
Countries
Switzerland
Contacts
Primary ContactThomas Müller, Professor
Outcome results
None listed