Aging, Healthy, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Conditions
Brief summary
This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.
Detailed description
Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.
Interventions
COMBINATION_PRODUCTmulti-modal targeted intervention (e.g., cognitive training, exercise, games)
The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)
Sponsors
Nanjing Brain Hospital
The Third People's Hospital of Yunnan Province
Central South University
Beijing academy of science and technology
Beijing University of Chinese Medicine
National Research Center for Rehabilitation Technical Aids
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults being able to walk at least a block, and * Adults with subjective cognitive decline (SCD), or * Adults with mild cognitive impairment (MCI), or * Adults with normal cognitive function
Exclusion criteria
* Clinical diagnosis of dementia * Adults who cannot follow the protocal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Cognitive function (SCD-9) | Change from Baseline Cognitive test results at 3 months. | The SCD-9 questionnaire is used to assess cognitive function of participants. |
| Change in Cognitive function (MoCA) | Change from Baseline Cognitive test results at 3 months. | The Montreal Cognitive Assessment test is used to assess cognitive function of participants. |
| Change in Cognitive function (AD8) | Change from Baseline Cognitive test results at 3 months. | The AD8 test is used to assess cognitive function of participants. |
| Change in Cognitive function (CDR) | Change from Baseline Cognitive test results at 3 months. | The Clinical Dementia Rating (CDR) test is used to assess cognitive function of participants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Physical capacity (TUG) | Change from Baseline physical capacity test results at 3 months. | The timed up and go (TUG) test is used to evaluate physical capacity of participants. |
| Change in Physical capacity (chair standing) | Change from Baseline physical capacity test results at 3 months. | The 30-second chair standing test is used to evaluate physical capacity of participants. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability] | Up to 24 months. | Number of participants with treatment-related adverse events as assessed by CTCAE v5.0. |
Countries
China
Contacts
Primary ContactYing Wang
Outcome results
None listed