The Continuous Positive Airway Pressure Effect on Rho-associated Coiled-coil Containing Kinases Activity.

The Continuous Positive Airway Pressure Effect on Rho-associated Coiled-coil Containing Kinases Activity and Left Ventricle Mass in Obstructive Sleep Apnea-hypopnea Syndrome.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05014529

Enrollment

160

Registered

2021-08-20

Start date

2021-10-01

Completion date

2024-12-31

Last updated

2021-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Keywords

Continuous positive airway pressure, Rho-associated coiled-coil containing kinases, Left ventricle mass

Brief summary

The ROCK (Rho-associated coiled-coil containing kinases) play a critical role in the pathogenesis of cardiovascular diseases and left ventricle hypertrophy (LVH). ROCK activity can be used as a clinical biomarker for the diagnosis and monitoring of cardiovascular disorders. Obstructive sleep apnea (OSA) increase cardiovascular disease and LVH. Continuous positive airway pressure (CPAP) is the standard therapy for OSA. This study investigate the effect of CPAP on ROCK activity and left ventricle mass.

Detailed description

The ROCK were discovered as downstream targets of Ras homologous A and regulate various important cellular functions, including proliferation, migration, adhesion, and apoptosis. They play a critical role in the pathogenesis of cardiovascular diseases, including cardiac fibrosis, hypertrophy, and remodeling. ROCK activity can be detected in human circulating leukocytes and could potentially be used as a clinical biomarker for the diagnosis and monitoring of cardiovascular disorders. It has been proven that higher ROCK activity is present in left ventricle hypertrophy (LVH) patients than those without LVH. Obstructive sleep apnea(OSA) is characterized by recurrent collapse of the pharyngeal airway during sleep that leads to intermittent nocturnal hypoxia, resulting in a broad range of cardiovascular morbidities, including coronary artery disease, heart failure, cardiac arrhythmias, and LVH. Continuous positive airway pressure (CPAP) is the standard therapy for OSA and several studies have shown that it can effectively reduce cardiovascular disease, but the effect of CPAP on left ventricle mass reduction is still uncertain. Previous studies demonstrated that patients with OSA had higher circulatory ROCK activity than those without OSA, but the role of CPAP on ROCK activity is not known. The circulatory leukocyte ROCK activity may be used as a clinical biomarker for cardiovascular disease and ROCK inhibitors may be used in the future as a treatment. OSA and CPAP treatment may also affect ROCK activity, the relationship between CPAP treatment, cardiac hypertrophy, and ROCK activity is important and should be clarified. Therefore, the main purpose of our study is to evaluate the effect of CPAP on ROCK activity and left ventricle mass.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

● Subjects who complete a standard polysomnography study.

Exclusion criteria

* Patients who have heart failure (as determined by clinical symptoms or signs with elevated brain natriuretic peptide and echocardiography showing structural or functional abnormalities) * Coronary artery disease (stress electrocardiography, myocardial scintigraphy, or coronary angiography proven coronary artery lesion) * Hypertrophic cardiomyopathy * Known infiltrative disease e.g. amyloidosis * Chronic kidney disease severe than stage III * Ischemic or hemorrhagic stroke * Central sleep apnea, * Hypoventilation syndrome (TCO2 or artery PaCO2 exceed 50 mmHg) * Unstable hemodynamic state * Eastern Cooperative Oncology Group Performance Status higher than grade 2 * Pregnant women will be excluded. * Polysomnography exam showing sleep time less than 2 hours * Patients who receive surgery or oral appliance during the study period

Design outcomes

Primary

Measure	Time frame	Description
ROCK activity	Check baseline blood ROCK 1, ROCK 2, and MYTP-1 p/t and follow up these levels in six months later.	Compare the change of blood ROCK 1, ROCK 2, and MYTP-1 p/t (The levels of phosphorylated to total myosin light chain phosphatase 1) among those three groups.
Left ventricle mass	Do baseline echocardiography and follow up echocardiography in six months later.	Compare the change left ventricle mass index among those three groups.

Secondary

Measure	Time frame	Description
Blood pressure	Obtain initial and blood pressure six months later.	Compare the blood pressure among those three groups.

Countries

Taiwan

Contacts

Primary ContactChung-Chieh Yu, MD

terminatorchieh@yahoo.com.tw886+22432-9292

Backup ContactNing-I Yang, MD

r3675@cgmh.org.tw886+22431-3131

Outcome results