Bladder Irritable
Conditions
Brief summary
Catheter-related bladder discomfort after transurethral resection of bladder tumor is frequent because of indwelling urinary catheter for irrigation. The mechanism of the catheter-related bladder discomfort is similar to that of overactive bladder, in which muscarinic acetylcholine receptors are stimulated. The catheter-related bladder discomfort is a well known predisposing factor for emergence delirium after general anesthesia. In this study, we aimed to compare the incidence of catheter-related bladder discomfort between dexmedetomidine only therapy and combind dexmedetomidine and glycopyrrolate therapy.
Interventions
DRUGGlycopyrrolate + dexmedetomidine
Intravenous glycopyrrolate before anesthetic induction. Dexmedetomidine administration during the surgery.
DRUGDexmedetomidine
Dexmedetomidine administration during the surgery.
Sponsors
Kangbuk Samsung Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists physical status I and II * elective transurethral resection of bladder tumor under general anesthesia
Exclusion criteria
* arrhythmia * bladder outflow obstruction * overacitve bladder * end stage renal disease * neurogenic bladder * morbid obesity * psychiatric disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of catheter-related bladder discomfort | 0 minute after entering the post-anesthetic care unit | No = not complaining of bladder discomfort on asking; Mild = report discomfot only on questioning; Moderate: report without questioning without behavior responses; Severe = report without questioniing accompanied by behavior responses. Mild, Moderate, Severe bladder discomfort is defined to have catheter-related bladder discomfort |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Delirium | 0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit | (1)acute and fluctuating changes in mental status (2)inattention (3)disorganized or incoherent thinking (4)altered level of consciousness. (1),(2) and (3), (1),(2), and (4), or (1)(2)(3)and (4) are defined to have deilrium. |
| Postoperative pain | 0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit | numerical rating scale (0=no pain to 10=worst pain imaginable) |
| Emergence agitation | 0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit | (1)calm (2)slightly agitated but consolable (3)moderately agitated and inconsolable (4)severely agitated and highly inconsolable |
| Dry mouth | 0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit | yes or no |
| postoperative nausea and vomiting | 0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit | yes or no |
| Sedation score | 0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit | (1)anxious, agitated or restless (2)cooperative, oriented and trranquil (3)responds to commands, asleep (4)brisk response to light glabellar taps or oud noise (5)sluggish response to light glabellar taps or loud noise (6)noresponse |
Outcome results
None listed