Ovarian Cancer
Conditions
Brief summary
Ovarian cancer is the third most common after endometrial and cervical cancer in societies with a high standard of living; It is the second most common type of gynecological cancer after cervical cancer in societies with a low standard of living, and it is also the deadliest among gynecological cancers. Dynamic thiol-disulfide homeostasis is an antioxidant system that minimizes oxidative damage and prevents cell damage. In the presence of oxidative stress, the thiol groups combine to form the disulfide structure, and when the oxidative stress condition is over, they are separated into thiol groups again. This homeostasis is impaired in conditions that cause oxidative processes such as diabetes, cardiovascular diseases, cancers, rheumatoid arthritis, and chronic kidney failure. This can be determined by measuring the total thiol and native thiol levels. Likewise, the level of ischemia modified albumin increases in the case of oxidative stress. There are studies on this homeostasis in the literature on many types of cancer; There are studies on endometrial cancer and cervical cancer, which are gynecological cancers In this study, the usability of these tests together with other diagnostic tests in the diagnosis of ovarian cancer will be evaluated.
Interventions
None listed
Sponsors
Tepecik Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* Histopathological diagnosis of ovarian cancer
Exclusion criteria
* Having an acute or chronic disease that will cause oxidative stress * Using alcohol/cigarettes/drugs * Using antioxidant agents (such as vitamins A, C, E)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| thiol - disulfide levels | April 2021 - January 2022 | the rate of total thiol, native thiol and total oxidant/antioxidant capacity |
Countries
Turkey (Türkiye)
Outcome results
None listed