Hypotension, Living Donor Liver Transplantation
Conditions
Brief summary
The Hypotension Prediction Index via the Edwards Hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients. The Hypotension Prediction Index is analyzed to verify the performance in predicting hypotensive events.
Detailed description
Hypotensive events during surgery and anesthesia occur frequently and are associated with complications such as myocardial infarction, acute kidney injury, and increase in mortality. Therefore predicting and preventing hypotension can lead to better outcomes. The Hypotension Prediction Index is monitored with the Edwards Hemosphere advanced monitoring system in living donor liver transplantation recipients via the radial artery. The monitor is blinded so that the anesthesiologist cannot see the index, and the anesthesiologist manages the blood pressure according to the institution's anesthetic protocol for liver transplantation. After the surgery is done, the Hypotension Prediction Index is analyzed to see how well the index predicted actual hypotension that occured during the liver transplantation surgery. Receiver operating characteristic curves are drawn to show the performance of the Hypotension Prediction Index in liver transplantation.
Interventions
Hypotension Prediction Index monitored via radial arterial line
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for living donor liver transplantation aged 20 years and older * Patients who understand the trial and have given informed consent
Exclusion criteria
* Patients with arrhythmia or pacemaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prediction of Hypotension 5 Minutes Before the Event | During the surgery | Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 5 minutes before the event |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prediction of Hypotension 10 Minutes Before the Event | During the surgery | Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 10 minutes before the event |
| Prediction of Hypotension 15 Minutes Before the Event | During the surgery | Receiver operating characteristic curve for the Hypotension Prediction Index, Comparison of the hypotensive event and the Hypotension Prediction Index 15 minutes before the event |
Countries
South Korea
Outcome results
None listed