Stomatitis
Conditions
Keywords
Stomatitis; oral ulcers; oral mucosa; tea; mouthwash
Brief summary
The aim of this study is to use a tea-based mouthwash to relieve pain and discomfort in patients with stomatitis and ulcers.
Detailed description
The objective of this study is to use tea as a base, supplemented with licorice to reduce bitterness and astringency, to make mouthwash, and use tea's antioxidant and anti-inflammatory properties to relieve the pain and discomfort of stomatitis and ulcer patients. This study will observe the difference between saliva and oral mucosal cells before and after treatment, to find the mechanism of effective treatment of stomatitis.
Interventions
COMBINATION_PRODUCTmouthwash with tea
Using tea as a base, supplemented with licorice to make mouthwash to relieve stomatitis.
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
age over 20 years old, male or female
Exclusion criteria
patients with oral cavity cancer, oropharyngeal cancer, and active bacterial infection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Xerostomia questionnaire (XQ) | 4 weeks | Questionnaires for symptoms relief of dry mouth |
| Xerostomia Inventory (XI) | 4 weeks | A multi-item approach to measuring dry mouth |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of oral mucosa cells with angiotensin-converting enzyme 2 (ACE2) staining (+) | 4 weeks | Immunohistochemistry stain for ACE2 protein |
Countries
Taiwan
Contacts
Primary ContactMing-Shao Tsai, M.D.
Outcome results
None listed