Ridge Splitting With Simultaneous Implant Placement Using i-PRF

Ridge Splitting With Simultaneous Implant Placement Using i-PRF With Guided Bone Regeneration: a Randomized Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05010785

Enrollment

Registered

2021-08-18

Start date

2021-08-20

Completion date

2022-11-15

Last updated

2023-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Implant, i-PRF, Ridge Splitting

Brief summary

Sohn introduced the concept of sticky bone in which i-PRF is mixed with the granules of bone graft, leading to fabrication of growth factors-enriched bone graft matrix using autologous fibrin glue. This minimizes bone loss and accelerates tissue healing during healing period. The present study was conducted to evaluate the clinical and radiographic outcomes following the application of the alveolar ridge splitting in combination with the use of guided bone regeneration (GBR) with or without i-PRF (sticky bone), associated with immediate implant placement in patients with horizontally atrophic jaw bones.

Interventions

PROCEDUREImmediate implant placement and alveolar ridge splitting with GBR and i-PRF

Implant insertion and GBR for augmentation of the gap between buccal and lingual plate using bone graft mixed with i-PRF

PROCEDUREImmediate implant placement and alveolar ridge splitting with GBR

Implant insertion and GBR for augmentation of the gap between buccal and lingual plate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* good general health at the time of surgery. * at least 3 months of healing after tooth extraction. * horizontally compromised alveolar ridges at least 10 mm high and 3 mm wide.

Exclusion criteria

* a vertical bone defect in the edentulous ridge. * thick cortex in the labial/buccal with less cancellous bone inside * obvious undercut on the labial/buccal side. * uncontrolled periodontal conditions or other oral disorders. * history of radiotherapy in the head and neck region. * uncontrolled diabetes mellitus or other systematic disorders. * smokers. * Pregnancy. * non-compliant patients. * allergic reaction to the medications used

Design outcomes

Primary

Measure	Time frame	Description
Measurements of the amount of bone formation in millimeters around immediately placed dental implants	9 months	Measurements of the amount of bone formation in millimeters using GBR with or without the combined effect of i-PRF in the ridge splitting following immediate implant placement.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026