Psoriasis
Conditions
Brief summary
This study investigates the effectiveness of a 24-week mindfulness intervention in reducing symptoms in psoriasis patients with anxiety and depression.
Detailed description
An adapted MBCT intervention will be offered to people with psoriasis with depression and/or anxiety. 8-week long MBCT therapy will be held between August 2021 and Jan 2022, based on the adapted protocol. The MBCT intervention will consist of 30-minute weekly groups focused on teaching mindfulness techniques and ways to recognize cognitive patterns that can increase anxiety and/or depression. Participants will be recruited from the community, according to the eligibility criteria detailed below. For all participants, anxiety and/or depressive symptom severity(SAS/SDS), PASI,DLQI,(as measured with standardized, validated scales) will be compared baseline and weeks 2;4;8;12;16;20;24. Itch intensity ,itch perception ,quality of sleep, hours missing at work ,helpfulness of common itch therapies serve as the secondary outcome, using a paired t-test.
Interventions
Mindfulness- Based Cognitive Therapy (MBCT) It involves practicing to be present 'in the moment' and an attitude of non- judgmental acceptance with the aim to maintain awareness, disengaging oneself from strong attachment and thereby developing a greater sense of emotional balance and well-being.
OTHERAntipsoriatic treatment
The routine drug therapy for psoriasis.
Sponsors
First Affiliated Hospital Xi'an Jiaotong University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* the age ranged from 18 to 70 years old * fulfilled the Classification Criteria for Psoriasis * the score of the SDS \> 50 and / or SAS \>50 * Participant has normal or corrected to normal vision and hearing * Participant is willing and able to give informed consent for participation in the study.
Exclusion criteria
* Participant has insufficient manual dexterity for the computerized tasks * severe systemic diseases * patients with severe mental illness or taking psychotic drugs * Pregnancy * No access to the internet
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline on the Psoriasis Area and Severity Index (PASI) | Baseline and Week 2;4;8;12;16;20;24 | PASI a measurement that combines severity of lesions and the area affected in one score that ranges from 0 to 72 . |
| Change from Baseline on the Dermatology Life Quality Index (DLQI) | Baseline and Week 2;4;8;12;16;20;24 | The DLQI is a 10-item questionnaire measuring the effect of dermatological diseases on patients over the last week. The DLQI total score is the sum of each individual item score and ranges from 0 or 1 to 30 . |
| Change from Baseline on the Self-rating Depression Scale (SDS) | Baseline and Week 2;4;8;12;16;20;24 | In the main component of the SDS , patients are asked 20 questions about Mental and physical feelings of emotional experience, and the patients determine the quality of emotion by selecting one of the options: Occasionally=1, sometimes=2, often=3, and continuously=4. |
| Change from Baseline on the Self-rating Anxiety Scale (SAS). | Baseline and Week 2;4;8;12;16;20;24 | In the main component of the SAS , patients are asked 20 questions about Mental and physical feelings of emotional experience, and the patients determine the quality of emotion by selecting one of the options: Occasionally=1, sometimes=2, often=3, and continuously=4. The total score is multiplied by an integer of 1.25 to get the standard score. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hours missing at work | Baseline and Week 2;4;8;12;16;20;24 | Approximate average hours missing at work due to itch per week from last visit. |
| Helpfulness of common itch therapies | Baseline and Week 2;4;8;12;16;20;24 | Questions regarding helpfulness of common itch therapies. |
| Itch perception | Baseline | Questions regarding situations in which the itch is especially bad (multiple choice options regarding day time, daily situations); objective assessment in which respondents are asked to select answers from the choices offered as a list |
Countries
China
Contacts
Primary ContactYan Zhou, professor
Backup ContactYan Zhao
Outcome results
None listed