Carnitine Supplementation and Skeletal Muscle Mass

Carnitine Supplementation and Skeletal Muscle Function in Aging

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05009641

Acronym

ROM

Enrollment

Registered

2021-08-17

Start date

2015-11-15

Completion date

2017-07-31

Last updated

2021-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Loss

Brief summary

The primary aim of the current research project is to investigate the effect of carnitine supplementation on muscle strength and body composition. A secondary aim of this project is to explore the effect of circulating trimethylamine N-oxide elevation, induced by carnitine supplementation on muscle strength and body composition.

Interventions

DIETARY_SUPPLEMENTL-carnitine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 29 Years

Healthy volunteers

Yes

Inclusion criteria

* must be able to swallow tablets

Exclusion criteria

* cardiovascular disease * liver disease * kidney disease * neuromuscular disease * gastrointestinal disorders (including stomach ulcers and erosions) * diabetes * other severe chronic diseases

Design outcomes

Primary

Measure	Time frame	Description
Muscle Strength using Biodex System 4 Pro dynamometer	24 weeks	Peak torque measured by performing maximum voluntary contractions during isometric knee extension and flexion. The test performed in concentric-concentric mode consisting maximum 4-s knee extensor isometric contraction and maximum 4-s knee flexor isometric contraction, separated by 20-s recovery, repeated three times. Muscle isokinetic strength assessed in 5 repetitions of flexion and extension at a speed of 60°/s. Muscle endurance assessed in 10 repetitions at 300°/s determine the ability of the muscle to maintain the work. Strength testing performed on the Biodex System 4 Pro dynamometer.
Body Composition: Body Fat Mass, Fat Free Mass, and Skeletal Muscle Mass using a bioelectrical impedance analyzer (InBody720)	24 weeks	The InBody720 measures impedance of five segments of the body (each arm, each leg, trunk) at frequencies of 1, 5, 50, 250, 500, and 1000 kHz through the 8-polar tactile-electrode. Based on the impedance, body fat mass, fat free mass, and skeletal muscle mass are calculated.

Secondary

Measure	Time frame	Description
Plasma trimethylamine N-oxide concentration	24 weeks	Blood samples taken before the start and after finishing the supplementation protocol. Plasma trimethylamine N-oxide determined using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) method

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026