Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity

Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity: A Randomized Controlled Trial In Poison Control Center Of Ain Shams University Hospitals

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05006638

Enrollment

Registered

2021-08-16

Start date

2022-12-31

Completion date

2023-12-31

Last updated

2022-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pesticide Poisoning

Brief summary

Intravenous lipid emulsion is an established, effective treatment for local anesthetic systemic toxicity. It is also efficacious in animal models of severe cardiotoxicity caused by a number of other medications. Recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs. The present study will focus on the potential role of intravenous lipid emulsion as an adjuvant therapy in pesticides toxicity.

Interventions

DRUGLipid Emulsion, Intravenous

Lipid emulsion is a mixture of soybean oil, egg phospholipids, glycerine, and is available in 10%, 20%, and 30% strengths. It has been used for decades as parenteral nutrition and for caloric supplementation and essential fatty acid deficiency. It has also been used as a carrier for lipid soluble medications

DRUGAtropine

a drug used as an antidote for some types of pesticides

DRUGToxogonin

a drug used as an antidote for some types of pesticides

DRUGSodium Bicarbonate Powder and ondansetron

standard of care for treatment of aluminuim phosphide is provided for patients poisoned with aluminuim phosphide

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients with acute pesticide intoxications with poison severity score 2 or 3 admitted in ICU of PCC-ASUH

Exclusion criteria

* Patients less than 18 years and more than 65 years. * Pregnant and lactating females. * Presence of medical diseases (e.g. renal, hepatic, cardiovascular, neurological diseases and chronic pancreatitis.) * Allergy to soya-, egg-or peanut protein

Design outcomes

Primary

Measure	Time frame	Description
mortality rate reduction	1 year	the primary end point is to lower the mortality rate for patients poisoned with pesticides
organ damage reduction	1 year	another primary end point is to reduce organ damage and injury for survivors

Countries

Egypt

Contacts

Primary ContactAya Sabry Mohamed

dr.ayasabry@gmail.com+201013910938

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026