Tricuspid Regurgitation
Conditions
Brief summary
The purpose of this research is to assess the severity of tricuspid regurgitation (a disorder in which the tricuspid valve in the heart does not close tight enough) using cardiac magnetic resonance imaging (MRI).
Detailed description
40 patients with moderate or more TR on echocardiography will undergo CMR/MRE with contrast to assess TR severity, and the associated extra-valvular cardiac and liver abnormalities as shown in the flow diagram below. Patients will continue their clinical management by their primary physicians as per the standards of care. 1-year follow up will be conducted via phone to inquire about patient's vital status (dead/alive), symptoms and hospitalizations.
Interventions
DIAGNOSTIC_TESTCardiac Magnetic Resonance
a non-invasive assessment to determine severity of tricuspid regurgitation
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Moderate or more tricuspid regurgitation
Exclusion criteria
1. Prior tricuspid valve prosthesis 2. Pacemaker/defibrillator that would impede MRI imaging 3. Planned tricuspid valve surgery 4. Primary liver pathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Severity of tricuspid regurgitation by cardiac magnetic resonance imaging | 1 year | Incidence of severity of TR by CMR as compared with current gold standard (TTE) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between severity of Tricuspid regurgitation by cardiac magnetic resonance imaging vs. elastography | 1 year | Correlation between severity of TR by CMR vs. echocardiography with 1-year composite endpoint of death, heart failure hospitalization, or tricuspid valve surgery. |
Countries
United States
Outcome results
None listed