Colchicine Adverse Reaction, Gout, Nonsteroidals (NSAIDs)Toxicity, Renal Impairment
Conditions
Keywords
Acute kidney injury, Renal impairment, Nonsteroidal antiinflammatory drug, Drug-drug interaction
Brief summary
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment regimens and evaluating risks of renal impairment.
Detailed description
Background: Gout is a common prevalent disease, which causes a low quality of life and poses a significant health burden nationally and internationally. Colchicine and Nonsteroidal anti-inflammatory drug (NSAID) are the mainstay treatment of gout. Concurrent use of colchicine and NSAIDs are more than half in all prescriptions of the gout patients. Both colchicine and NSAIDs may cause renal impairment. However, the empirical evidence of renal impairment of colchicine and NSAIDs combination therapy is limited and even absent. Objectives: This proposal will assess the association between colchicine and NSAIDs combination therapy and acute kidney injury. The investigators further evaluate the relationships of duration-response, recency-response, and dose-response.
Interventions
DRUGColchicine and NSAID
Colchicine and nonsteroidal anti-inflammatory drug combination therapy
Sponsors
En Chu Kong Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of a gout diagnosis * Initially receiving at least one anti-gout drug
Exclusion criteria
* \<1 year of continuous health insurance enrollment * Colchicine and NSAID use before the cohort entry date * Patients with hemodialysis or peritoneal dialysis before the cohort entry date * Patients with acute kidney injury before the cohort entry date
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute kidney injury | Through study completion, an average of 1 year | Number of participants with a diagnosis of acute kidney injury |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All cause mortality | Through study completion, an average of 1 year | Number of participants with a death record |
| Hemodialysis or peritoneal dialysis | Through study completion, an average of 1 year | Number of participants with a dialysis record |
Outcome results
None listed