Effects of Plasmapheresis on Aging Biomarkers

Studie Vlivu darování krevní Plazmy - Plasmapheresis. Study of the Plasma Donation Effect - Plasmapheresis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05004220

Enrollment

Registered

2021-08-13

Start date

2021-04-06

Completion date

2023-02-10

Last updated

2023-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Plasmapheresis

Keywords

Aging, Plasmapeheresis

Brief summary

The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.

Interventions

PROCEDUREPlasmapheresis

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.

Study design

Observational model

CASE_CROSSOVER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

1. Generally healthy volunteer subjects age 40 - 60 2. 50:50 man and woman

Exclusion criteria

1. Subjects excluded from plasma donation protocols (serious illness, infection, etc) 2. Subjects undergoing stronger anti-aging interventions

Design outcomes

Primary

Measure	Time frame	Description
Significant change of biological age according to epigenetic clock after 8 plasmaphereses	Through study completion, an average of 8 months	Significant change of the epigenetic age of the plasma donors after 8 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.

Secondary

Measure	Time frame	Description
Significant change of biological age according to epigenetic clock after 8 plasmaphereses	Through study completion, an average of 8 months	Significant change of the epigenetic age of the plasma donors after 4 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.
Significant change of the proteomic profile after 8 plasmaphereses	Through study completion, an average of 8 months	Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.
Significant change of the proteomic profile after 4 plasmaphereses	Through study completion, an average of 8 months	Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.
Significant change of the biological age according to a blood biochemistry clock after 8 plasmaphereses	Through study completion, an average of 8 months	Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.
Significant change of the biological age according to a blood biochemistry clock after 4 plasmaphereses	Through study completion, an average of 8 months	Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 5, 2026