Multiple Sclerosis
Conditions
Keywords
Multiple sclerosis, Thalamus, Nuclei, Atrophy
Brief summary
The thalamus is composed of several nuclei interlocked in a complex anatomy. In multiple sclerosis (MS), the thalamus can be altered due to disconnection by white matter lesions and due to direct damages that could be partly mediated by CSF. Due to such pathophysiology and complex anatomy, some nuclei could be more vulnerable to multiple sclerosis than others. We will test this hypothesis by using a new algorithm to automatically segment several nuclei that we will be applied to the French national MS database
Interventions
None listed
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
University Hospital, Bordeaux
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
: * Patient older than 18 years old. * With Multiple Sclerosis according to Mc Donald 2017 criteria or with clinically isolated syndrome and included with OFSEP cohort. * Phenotype known (RR, SP, PP or CIS). * Date of diagnosis known. * With at least one MRI that includes 3D T1 and FLAIR at 1.5T or 3T.
Exclusion criteria
: * Stroke * Other causes of dementia not caused by Multiple Sclerosis (Alzheimer's disease, Parkinsonian syndromes…)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Volume of thalamic nuclei | At inclusion in the cohort | Volume of individual thalamic nuclei according to disease duration. |
Countries
France
Contacts
Primary ContactThomas Tourdias, Pr
Outcome results
None listed