Cystic Fibrosis
Conditions
Brief summary
With this retrospective observational cohort study, we performed a longitudinal assessment of the renal function of the adult CF patients who underwent LUTX, aiming 1) to describe possible risk factors associated with perioperative AKI and 2) to describe AKI short and long term effects on clinical outcomes.
Detailed description
This study is a retrospective analysis of prospectively collected data from medical records of all consecutive CF patients who underwent LUTX at our Institution from January 2013 to December 2018.
Interventions
PROCEDURELung Transplantation
Double lung transplant
Sponsors
Policlinico Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients with CF who underwent LUTX during the study period were considered.
Exclusion criteria
* single LUTX * re-transplantation * missing medical records; * age \< 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute Kidney Injury | 1 month | AKI stage 1, stage 2, and stage 3 whether a 1.5-1.9 times, 2-2.9 times, and \>3 times increase from the preoperative creatinine was measured, respectively. Following KIDGO criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival | Until May 31 2021 | Death at follow-up |
Other
| Measure | Time frame | Description |
|---|---|---|
| Chronic Kidney Injury | 1 year after lung transplantation | chronic kidney disease (CKD) at 1-year follow-up was defined according to KIDGO criteria: an eGFR between 90 to 60 mL/min/1.73 m2 was considered to be stage 2 CKD, between 30-to-59 mL/min/1.73 m2 was considered to be stage 3 CKD, between mL/min/1.73 m2 was classified as stage 4, and \< 15 mL/min/1.73 m2 (or need for dialysis or kidney transplant) was considered to be stage 5 |
Countries
Italy
Outcome results
None listed