Gene Deletion, Gene Insertions
Conditions
Keywords
sports medicine, platform, sample database, gene
Brief summary
Preserve biological samples and gene extracts of all sports medicine-related diseases. To study related gene mutation sites and regulation. To study related molecular mechanisms and signaling pathways. A storage platform for sports medicine-related diseases research sample database has been established.
Interventions
None listed
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. Patients with joint sports injuries. 2. Follow-up patients after sports injury. 3. Patients with genetic predisposition to sports injuries. 4. Patients with family genetic predisposition to exercise-related diseases and their relatives.
Exclusion criteria
1. Patients with joint damage caused by external force. 2. The patient is accompanied by other injuries at the same time.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Magnetic resonance imaging (MRI) | Before the operation | All MRI scans were obtained with a 3.0-T MRI scanner (Magnetom Trio with TIM system, Siemens Healthcare). Five routine MRI sequences with a section thickness of 4 mm were obtained in all patients. Preoperative and postoperative evaluations of the articular cartilage of the transplanted compartment were performed with the Yulish score41 (grade 0 = normal; grade 1 = normal contour 6 abnormal signal; grade 2 = superficial fraying, erosion, or ulceration of \<50%; grade 3 = partial-thickness defect of \>50% but \<100%; grade 4 = full-thickness cartilage loss). The signal of the meniscus allograft in the coronal plane of the T2-weighted fast spin echo sequence was graded on a scale of 0 to 3. |
| Radiographs | Before the operation | All patients also obtained 45° flexion weightbearing AP radiographs of both the ipsilateral and contralateral sides at final follow-up. The radiograph of the total length of the lower limbs was used to evaluate alignment. In the AP plain radiographs, the shortest distance between the femoral condyle and tibial plateau of the transplanted side was measured and designated as the joint space height. The difference between the ipsilateral and contralateral sides was calculated to identify joint space narrowing. In addition, Kellgren-Lawrence (K-L) grading was used to assess the osteoarthritic status of the knee. |
Countries
China
Contacts
Primary ContactJia-Kuo Yu
Backup ContactLin Lin
Outcome results
None listed