Cirrhosis, Esophageal Neoplasms, Portal Hypertension
Conditions
Brief summary
Cirrhotic patients may be at high risk for esophageal cancer. Endoscopic resection is the standard treatment for superficial tumors. However, cirrhosis might be associated with upper gastrointestinal bleeding, particularly in case of portal hypertension or coagulopathy. This study aims to assess safety, efficacy and methods to prevent potential complications in cirrhosis or portal hypertension context for esophageal endoscopic resection. This retrospective multicentric French-Belgian study includes all consecutive patients with cirrhosis or portal hypertension who underwent esophageal endoscopic resection from January 2005 to 2021.
Interventions
PROCEDUREEndosocpic resection of early esophageal tumor
under general anesthesia, by mucosectomy or endoscopic submucosal dissection
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* older than 18 years with cirrhosis or portal hypertension who underwent endoscopic resection of an early esophageal tumor
Exclusion criteria
* younger than 18
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| technical success of early esophageal cancer resection | baseline | defined by a complete macroscopic resection |
Secondary
| Measure | Time frame |
|---|---|
| adverse events per procedure (immediate bleeding, perforation) | baseline |
| morbidity post procedure (delayed bleeding, infection, esophageal stenosis, 30-days related liver decompensation, 30-days related mortality) | up to 4 weeks |
| Potential risk factors for adverse events | baseline |
| preemptive methods to the risk of bleeding | baseline |
Outcome results
None listed