Blood Pressure, Inflammation
Conditions
Brief summary
The goal of this study is to determine the impact of dietary sodium and fructose on blood pressure and inflammation in young healthy adults.
Detailed description
Excess dietary salt is associated with an increased risk of cardiovascular diseases. Some healthy adults have been determined to be more sensitive to dietary salt than others, which can result in a 10% or more increase of blood pressure. The mechanisms underlying salt sensitivity of blood pressure are not fully understood. Previous research has suggested excess intake of added sugars, especially fructose, can increase salt sensitivity of blood pressure. Chronic elevated consumption of salt and fructose independently have been shown to have damaging effects on the body, however, the combination of both salt and fructose has not been fully studied in humans. The purpose of this research study is to determine if increased dietary fructose consumption will stimulate salt-sensitive hypertension and induce proinflammatory cytokines through activation of the immune system. Understanding how the body regulates blood pressure during times of elevated salt and fructose is important for determining cardiovascular risk in a population with normal blood pressure.
Interventions
DIETARY_SUPPLEMENTRecommended sodium and low fructose diet
Upon completion of a 7 day dietary intervention of consuming the daily recommended sodium and low fructose contents we will investigate changes in ambulatory blood pressure, urinary sodium excretion, heart rate variability, secretion of inflammatory cytokines, and reactive oxygen species.
DIETARY_SUPPLEMENTHigh sodium and low fructose diet
Upon completion of a 7 day dietary intervention of consuming the daily high sodium and low fructose contents we will investigate changes in ambulatory blood pressure, urinary sodium excretion, heart rate variability, secretion of inflammatory cytokines, and reactive oxygen species.
DIETARY_SUPPLEMENTHigh sodium and high fructose diet
Upon completion of a 7 day dietary intervention of consuming the high sodium and high fructose contents we will investigate changes in ambulatory blood pressure, urinary sodium excretion, heart rate variability, secretion of inflammatory cytokines, and reactive oxygen species.
Sponsors
University of Delaware
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* normal blood pressure * males, females, minorities
Exclusion criteria
* high blood pressure * body mass index (BMI) of \> 30 kg/m2 * smokers or nicotine users * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 24-hour Blood Pressure | Day 7 of diet intervention | Systolic blood pressure over 24 hours (mmHg) |
| Inflammatory cytokines | Day 7 of diet intervention | ELISA assay detecting Interleukin-6 and tumor necrosis factor-alpha |
Countries
United States
Outcome results
None listed