Mild Cognitive Impairment, Prodromal Alzheimer's Disease
Conditions
Keywords
Ultrahigh Field MRI, 7T MRI, QSM
Brief summary
A longitudinal observational neuroimaging study of individuals with Early Onset Alzheimer's disease during the prodromal phase, and matched control group - Ultrahigh Field MRI study at 7T
Detailed description
This study aims to determine whether high resolution MRI at 7T and Quantitative Susceptibility Mapping (QSM) can demonstrate a specific pattern of iron overload in strategically important areas of brain as a sensitive marker of pathological Alzheimer's disease i.e. patients with subjective or mild cognitive impairment associated with Amyloid or tau pathological state in the cerebrospinal fluid.
Interventions
OTHERMRI at 7T
MRI at 7T
Sponsors
Nottingham University Hospitals NHS Trust
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* Ability to provide informed consent * Patients with pathological diagnosis of Alzheimer's disease according to the National Institute on Aging and Alzheimer's Association, NIA-AA, criteria (Alzheimer's group) or cognitively normal individuals within 1.5 standard deviation of normal in all tests (control group)
Exclusion criteria
* Lack of mental capacity to consent to study involvement * Not speaking English before age 5 years * Learning disability * Schizophrenia * Substance misuse * Implanted devices not certified as compatible with ultra-high field MRI (e.g. cardiac pacemaker) * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative Susceptibility Mapping, QSM (from 7T MRI data) to hippocampal subfield volume loss at 1 year | one year | Relationship between QSM at recruitment and to hippocampal subfield volume (QSM and hippocampal subfield volume are obtained from 7T MRI Susceptibility Weighted and T1 Weighted images) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cross-sectional and longitudinal changes in QSM in the hippocampal subfields | one year | cross-sectional and longitudinal changes in QSM in the local hippocampal subfield QSM and volume loss after 1 year. QSM and hippocampal subfields volume will be obtained from 7T MRI data |
| neuropsychological measures in relation to QSM and volume loss in hippocampal subfields | one year | neuropsychological measures at 0 and 12 months in relation to QSM and volume loss in hippocampal subfields (adjusted for APOe). QSM and hippocampal subfield volume loss are obtained from 7T MRI Susceptibility Weighted and T1 Weighted images. |
Countries
United Kingdom
Contacts
Primary Contactrebecca Boulton
Backup ContactHannah Sargisson
Outcome results
None listed