Sarcoma,Soft Tissue
Conditions
Keywords
Mixofibrosarcoma
Brief summary
Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017. The study will exam all the clinical, radiological, histological and immunohistochemical features of this tumour in all samples and in a limited serie of cases the presence of mutation of 50 genes cancer related.
Interventions
OTHERcase series review of clinical and histological data
We will review all the medical records, radiological imaging, and histological data of these cases. The immunohistochemical analysis of the principal alterated genes identified in this tumor will be performed.
Sponsors
Istituto Ortopedico Rizzoli
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male and female patients treated at Rizzoli Institute from 01 Jan 1993 to 01 Dec 2017 2. Diagnosis of mixofibrosarcoma of extremities 3. Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis and molecular analysis 4. Enough tumor biobanked material available for molecular analysis 5. Presence of the biobank signed informed consent 6. Written informed consent prior to any study-specific analysis and/or data collection
Exclusion criteria
1\) Patients with histological diagnosis different from mixofibrosarcoma of extremities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| disease-free survival | at baseline (Day0) | identify patients with different risk classes in terms of disease-free survival (local and systemic recurrence). |
| overall survival | at baseline (Day0) | identify patients with different risk classes in terms of overall survival. |
Countries
Italy
Outcome results
None listed