Blood Glucose, Low, Hunger
Conditions
Brief summary
The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger & satiety.
Detailed description
The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.
Interventions
DRUGLactisole
sweet taste inhibitor (decreases sweetness)
DRUGRebaudioside M
Sweetener (increases sweetness)
OTHERSucrose
10% Sucrose corresponding to a regular soft drink
Sponsors
University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* male * healthy * non-smoking * normal taste responses towards sweet taste
Exclusion criteria
* female * regular smokers * disturbed glucose and/or lipid metabolism * regular intake of medication * known allergies against one of the test compounds * ageusia * alcohol or drug addiction * intake of antibiotics within the past 2 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood glucose concentration | over a time span of 120 minutes after drinking the test solution | Glucose concentration \[mg/dL\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution |
| Insulin concentration | over a time span of 120 minutes after drinking the test solution | Insulin concentration \[mmol/L\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution |
| GLP-1 concentration | over a time span of 120 minutes after drinking the test solution | Glucagon-like peptide 1 concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution |
| GIP-concentration | over a time span of 120 minutes after drinking the test solution | Gastric inhibitory polypeptide concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Food intake | 120 minutes after drinking of the test solution | Ad libitum Food intake from a standardized breakfast |
| Metabolic changes | over a time span of 120 minutes after drinking the test solution | Metabolome analysis in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution |
Countries
Austria
Outcome results
None listed