Brain-based Understanding of Individual Language Differences After Stroke

Understanding the Brain Basis of Language and Cognitive Functions Through the Study of Individuals With Brain Injury and Healthy Controls

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04991519

Acronym

BUILD

Enrollment

400

Registered

2021-08-05

Start date

2018-11-01

Completion date

2028-08-30

Last updated

2024-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alexia, Aphasia, Stroke

Keywords

aphasia, stroke, brain injury, speech, language, reading, alexia, apraxia

Brief summary

Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Stroke Survivors: * Age \>=18 * Stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia * Learned English at 8 years or younger Controls: * Age \>=18 * No history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor * Learned English at 8 years or younger

Exclusion criteria

* History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia) * Severe psychiatric condition that would interfere with participation in the study * History of a learning disability that could impact interpretation of results Additional

Design outcomes

Primary

Measure	Time frame	Description
MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)	Collected within 1 month of behavioral testing	Part of MRI sequence that measures deep grey matter structure.
DTI (Diffusion Tensor Imaging)	Collected within 1 month of behavioral testing	Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.
Behavioral testing	Collected within 1 month of MRI	Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.

Countries

United States

Outcome results