Exercise
Conditions
Keywords
intradialytic exercise, hemodialysis, health-related quality of life
Brief summary
This study aimed to evaluate the effects of intradialyic exercise on dialytic parameters, HRQL, and depression status in hemodialysis patients. A randomized controlled trial was conducted. Sixty-four participants were recruited using stratified random sampling and allocated with a 1:1 randomization ratio to either experimental group (EG, treated in odd weekdays, n = 32) or comparison group (CG, treated in even weekdays, n = 32). The EG received a 12-week intradialytic exercise, while the CG maintained usual lifestyles. Dialytic parameters, HRQL, and depression status were collected at baseline and at 12 weeks. The results indicated that there were no differences in changes of dialytic parameters from baseline between EG and CG. However, the EG had increased HRQL and reduced depression status at 12 weeks compared with the CG. A 12-week intradialytic exercise is safe, feasible and effective in improved HRQL and reduced depression status for hemodialysis patients.
Detailed description
Exercise has been shown to be of fundamental importance in managing chronic diseases and improving health-related quality of life (HRQL) as well as psychological health. However, whether intradialyic exercise is safe and has positive impact on HRQL and depression status in hemodialysis patients requires further researches with diverse racial and cultural groups to clarify. This study aimed to evaluate the effects of intradialyic exercise on dialytic parameters, HRQL, and depression status in hemodialysis patients. A randomized controlled trial was conducted at a medical center in Northern Taiwan. Sixty-four participants from 112 eligible hemodialysis patients were recruited using stratified random sampling and allocated with a 1:1 randomization ratio to either experimental group (EG, treated in odd weekdays, n = 32) or comparison group (CG, treated in even weekdays, n = 32). The EG received a 12-week intradialytic exercise (supine lower-limb ergometer, 30 minutes/session, 3 sessions/week), while the CG maintained usual lifestyles. Dialytic parameters (serum chemistries, serum electrolytes, and estimated glomerular filtration rate), HRQL, and depression status were collected at baseline and at 12 weeks. The results indicated that there were no differences in changes of dialytic parameters from baseline between EG and CG. However, the EG had increased HRQL (ß = 22.6, p\<.001) and reduced depression status (ß = -7.5, p = .02) at 12 weeks compared with the CG. A 12-week intradialytic exercise is safe, feasible and effective in improved HRQL and reduced depression status for hemodialysis patients.
Interventions
BEHAVIORALa 12-week intradialytic exercise
a 12-week intradialytic exercise (supine lower-limb ergometer, 30 minutes/session, 3 sessions/week)
Sponsors
Tri-Service General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
outcome assessor was blinded to the group assignment
Intervention model description
A randomized, controlled trial with a two parallel-group design
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* (1) ESRD patients on maintenance of hemodialysis; (2) aged 20 to 80 years; (3) able to speak and understand Mandarin; (4) had received regular treatment with hemodialysis (3 times/ week) for at least 6 months; (5) agreed to be randomized to one of the two groups.
Exclusion criteria
* lower limb disabilities, hospitalized patients, treatment with peritoneal dialysis, received hemodialysis less than 3 times/ week, a history of recent acute myocardial infarction, unstable angina, uncontrolled arrhythmia, acute stroke, hospitalization experience within 6 months, cancer, and diagnosed with mental illness, especially depression.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dialytic parameters: GPT [IU/l] | Change from baseline [IU/l] assessed by blood analysis at 12 weeks | GPT \[IU/l\] |
| Dialytic parameters: GOT [IU/l] | Change from baseline GOT [IU/l] assessed by blood analysis at 12 weeks | GOT \[IU/l\] |
| Dialytic parameters: red blood cell [count/ul] | Change from baseline red blood cell [count/ul] assessed by blood analysis at 12 weeks | red blood cell \[count/ul\] |
| Dialytic parameters: hemoglobin [g/dl] | Change from baseline hemoglobin [g/dl] assessed by blood analysis at 12 weeks | hemoglobin \[g/dl\] |
| Dialytic parameters: hematocrit [%] | Change from baseline hematocrit [%] assessed by blood analysis at 12 weeks | hematocrit \[%\] |
| Dialytic parameters: mean corpuscular volume [fl] | Change from baseline mean corpuscular volume [fl] assessed by blood analysis at 12 weeks | mean corpuscular volume \[fl\] |
| Dialytic parameters: albumin [g/dl] | Change from baseline albumin [g/dl] assessed by blood analysis at 12 weeks | albumin \[g/dl\] |
| Dialytic parameters: blood urea nitrogen [BUN, mg/dl] | Change from baseline blood urea nitrogen [BUN, mg/dl] assessed by blood analysis at 12 weeks | blood urea nitrogen \[BUN, mg/dl\] |
| Dialytic parameters: creatinine [Cr, mg/dl]) | Change from baseline creatinine [Cr, mg/dl]) assessed by blood analysis at 12 weeks | creatinine \[Cr, mg/dl\]) |
| Dialytic parameters: sodium [Na, mEq/l] | Change from baseline sodium [Na, mEq/l] assessed by blood analysis at 12 weeks | sodium \[Na, mEq/l\] |
| Dialytic parameters: potassium [K, mEq/l] | Change from baseline potassium [K, mEq/l] assessed by blood analysis at 12 weeks | potassium \[K, mEq/l\] |
| Dialytic parameters: calcium [Ca, mg/dl] | Change from baseline calcium [Ca, mg/dl] assessed by blood analysis at 12 weeks | calcium \[Ca, mg/dl\] |
| Dialytic parameters: phosphate [P, mg/dl] | Change from baseline phosphate [P, mg/dl] assessed by blood analysis at 12 weeks | phosphate \[P, mg/dl\] |
| Dialytic parameters: IPTH [pg/ml] | Change from baseline IPTH [pg/ml] assessed by blood analysis at 12 weeks | IPTH \[pg/ml\] |
| Dialytic parameters: estimated GFR [ml/min1.73m2]) | Change from baseline estimated GFR [ml/min1.73m2]) assessed by estimation based on serum creatinine at 12 weeks | estimated GFR \[ml/min1.73m2\]) |
| health-related quality of life assessed by the scale of SF-36 | Change from baseline health-related quality of life at 12 weeks | self-reported health-related quality of life |
| depression status assessed by the scale of Beck Depression inventory | Change from baseline depression status at 12 weeks | self-reported depression status |
Countries
Taiwan
Outcome results
None listed