Gastric Cancer, Helicobacter Pylori Infection, Precancerous Lesion
Conditions
Brief summary
Pepsinogens (PGs) can be used for gastric cancer (GC) screening, but the cutoff levels vary among studies, and PG levels are influenced by numerous factors. To examine the diagnostic value of PG levels and Helicobacter pylori (Hp) status for GC and precancerous lesions screening in asymptomatic individuals undergoing health checkup in China.
Detailed description
Pepsinogens (PGs) can be used for gastric cancer (GC) screening, but the cutoff levels vary among studies, and PG levels are influenced by numerous factors. To examine the diagnostic value of PG levels and Helicobacter pylori (Hp) status for GC and precancerous lesions screening in asymptomatic individuals undergoing health checkup in China. We operated a multicenter cross-sectional study of subjects who underwent health checkup at nine International Healthcare Centers in China. All participants underwent gastroscopy and pathological examination, serum PG, 13C-urea breath test, and/or Hp serological current infection marker rapid test, all on the same day. PG related parameters were analyzed in different Hp subgroups and regions.
Interventions
DIAGNOSTIC_TESTpepsinogen
serum pepsinogen diagnosed gastric cancer and precanceous lesion
Sponsors
Jilin City People's Hospital
No. 924 Hospital of the People's Liberation Army of China
Kunshan Hospital of Traditional Chinese Medicine
Chinese PLA General Hospital
Sichuan Provincial People's Hospital
Affiliated Hospital of Southwest Medical University
Zhongshan Hospital Xiamen University
Jingzhou Hospital of Traditional Chinese Medicine
Changhai Hospital
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
intention to undergo gastroscopy during health checkup examination 25-75 years of age.
Exclusion criteria
a history of gastric ulcer, gastric polyp, or GC a history of gastrectomy treatment with a proton pump inhibitor in the last month contraindications to gastroscopy a history of Hp eradication a history of abdominal pain, abdominal distention, belching, acid reflux, nausea and other digestive tract symptoms within 1 month incomplete data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum pepsinogen levels for GC and precancerous lesions | 1 year | cutoff values of pepsinogen level for GC and precancerous lesions in different regions in China and in different HP status |
| Risk factors for GC | 1 year | the risk factors for GC, according to the logistic regression model |
Countries
China
Contacts
Primary ContactZhenya Song, Dr.
Backup ContactYuling Tong, Dr.
Outcome results
None listed