Quantification of Cannabinoids and Comparison to Post-Surgical Pain Medication Requirements and Surgical Outcomes

Quantification of Endo- and Phytocannabinoids With Comparison to Pain Medication Requirements and Surgical Outcomes for Patients Undergoing Abdominal Surgery for Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04988490

Enrollment

Registered

2021-08-03

Start date

2021-10-11

Completion date

2024-06-14

Last updated

2025-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer, Cannabis Use, Post-Surgical Complication, Post-Surgical Pain

Keywords

Cannabis, Post-Surgical Complications, Post-Surgical Pain, Abdominal Surgery

Brief summary

To determine how daily cannabis use affects surgical outcomes.

Detailed description

To determine if patients who are daily cannabis users that are undergoing inpatient abdominal surgery for the treatment of cancer are different from non-cannabis users regarding phytocannabinoid and endocannabinoid levels, pain scores, pain medication requirements, and surgical complications.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients \> 18 years old * Undergoing abdominal surgery for the treatment of cancer * Report no cannabis use in the last year or chronic cannabis use (defined as at least weekly use for 3 months or more)

Exclusion criteria

* patients with chronic pain, chronic pain syndrome on opioids * female patients who are pregnant or lactating * patients who report use of illicit substances

Design outcomes

Primary

Measure	Time frame	Description
Postoperative opioid consumption	30 days	Postoperative opioid consumption among daily cannabis using and non-cannabis using patients undergoing abdominal surgery for cancer
Correlation of postoperative opioid consumption	30 days	Correlation between serum phytocannabinoid and endocannabinoid levels, pain scores, and postoperative opioid consumption
Correlation of postoperative complications	30 days	Correlation between 30-day post-operative complications, preoperative, and postoperative phytocannabinoid and endocannabinoid levels

Countries

United States

Outcome results